Evidence map›Paper›PMID 40012754›Full record

ArticleRoyal Society open science2025

Push-pull fluorophores based on NHS esters of bithiophene for labelling of biomolecules containing primary amines.

Mariana Barros, Pau Arroyo, Jose A Sáez, Salvador Gil, Margarita Parra, Susana P G Costa, M Manuela M Raposo, Pablo Gaviña

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Royal Society open science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariana BarrosInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.
Pau ArroyoInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.ORCID https://orcid.org/0000-0001-9290-3714
Jose A SáezInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.
Salvador GilInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.
Margarita ParraInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.
Susana P G CostaCenter of Chemistry, University of Minho, Campus de Gualtar, Braga 4710-57, Portugal.
M Manuela M RaposoCenter of Chemistry, University of Minho, Campus de Gualtar, Braga 4710-57, Portugal.ORCID https://orcid.org/0000-0002-7996-1626
Pablo GaviñaInstituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat de València, Universitat Politècnica de València, c/ Doctor Moliner 50, Burjassot, Valencia 46100, Spain.ORCID https://orcid.org/0000-0002-8496-6448

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorescent labelling is a versatile tool to visualize biomolecules containing primary amines in their cellular environment, allowing the study of their function or interactions. Here, three organic fluorophores that can irreversibly bind to the primary amine group on the target biomolecule are reported. They consist of push-pull heterocyclic dyes based on bithiophene and incorporating a terminal

Indexed as

bithiopheneBoc-lysinefluorescent labellingprimary amine chemosensorpush–pull heterocyclic fluorophores

Identifiers

PMID40012754
PMCPMC11863869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.