Evidence map›Paper›PMID 40012743›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2025

Cytotoxic Responses Mediated by NK Cells and Cytotoxic T Lymphocytes in Xenotransplantation.

Viktoriia Galdina, Gisella L Puga Yung, Jörg D Seebach

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Viktoriia GaldinaDepartment of Medicine, Laboratory of Translational Immunology, Division of Immunology and Allergy, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Gisella L Puga YungDepartment of Medicine, Laboratory of Translational Immunology, Division of Immunology and Allergy, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Jörg D SeebachDepartment of Medicine, Laboratory of Translational Immunology, Division of Immunology and Allergy, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

Funding

Swiss National Science Foundation CRSII5_198577
6 · The paper itself

Abstract

Xenotransplantation represents a potential solution to the shortage of organs for transplantation. The recent advancements in porcine genetic modification have addressed hyperacute and acute vascular rejection; however, challenges persist with regard to delayed xenograft rejection. Porcine endothelial cells (pECs) represent a crucial target in the context of xenograft rejection, which is mediated by cytotoxic lymphocytes. It is crucial to comprehend the manner in which human natural killer (NK) cells and cytotoxic CD8

Indexed as

Killer Cells, NaturalT-Lymphocytes, CytotoxicTransplantation, HeterologousAnimalsCytotoxicity, ImmunologicEndothelial CellsGraft RejectionGraft SurvivalHumansSwineCD8+ T cellscytotoxicityNK cellsporcine endotheliumxenograft rejection

Identifiers

PMID40012743
PMCPMC11862997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.