ArticleFrontiers in neuroscience2025
Bedside cerebral microvascular imaging of patients with disorders of consciousness: a feasibility study.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Functional Ultrasound Imaging of Auditory Responses in Comatose Patients.Research (Washington, D.C.) · 2025Article
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9 authors.
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Abstract
Background: Efficient bedside neurofunctional monitoring is crucial for managing disorders of consciousness (DoC). Ultrafast Power Doppler Imaging (uPDI) outperforms traditional Ultrasound in bedside for assessing the microcirculatory system. However, intracranial blood flow imaging traditionally faces limitations due to the skull's impedance. This constraint is circumvented in common post-craniectomy DoC patients, who present a unique observational window for uPDI. Methods: We conducted uPDI scans on five DoC patients of different ages and consciousness levels who had undergone decompressive craniectomy. We compared the imaging results from uPDI with traditional PDI and identified the physiological and pathological conditions with uPDI. Results: Detailed microvascular images of both cortical and subcortical areas were obtained using uPDI through the craniectomy window. Notably, uPDI demonstrates high sensitivity and imaging depth, revealing microvessels as small as 320 μm in diameter at 4 cm depth, and detecting blood flow signals up to 6 cm beneath the scalp. Conclusion: Through the decompressive cranial windows of DoC patients, we obtained cerebral microvascular images with significantly higher sensitivity without the need for contrast agents. Significance: Our research provides a novel bedside cerebral microcirculation imaging method for patients with DoC, offering convenient neurofunctional assessment to improve the clinical management of DoC patients.
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