ArticleBrain circulation
Association of baseline plasma fibrinogen levels with cognitive and affective status at 30 and 90 days in individuals with ischemic stroke: A prospective study from Nigeria.
Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Interaction between Brain Natriuretic Peptide and QTc Prolongation on Mortality in Patients with Stroke-Heart Syndrome.Aging and disease · 2025Article
- Immune alterations in vestibular neuritis: a retrospective database pilot study on T and B lymphocyte profiles and cytokine levels.Frontiers in neurologyArticle
- Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe influence of fibrinogen as a risk factor in developing poststroke neuropsychological and cognitive problems is underreported. This study aimed to evaluate the relationship between baseline fibrinogen levels and depression, anxiety, and cognition 30- and 90-day after stroke.
methodsThis prospective study involved 48 patients with first-ever mild-to-moderate ischemic stroke, whose plasma fibrinogen levels were assessed within 24 h of stroke onset. Clinical depression, anxiety, and cognitive impairment were evaluated by the Hospital Anxiety and Depression Scale and Montreal Cognitive Assessment at 30- and 90-day after stroke.
resultsAfter adjusting for important covariates, the multiple linear regression models showed that baseline plasma fibrinogen was associated with the symptoms of depression, anxiety, and cognitive decline at both 30- and 90-day follow-up (
conclusionsHigh levels of baseline plasma fibrinogen are associated with the onset and severity of symptoms of depression, anxiety, and cognitive decline at 30 and 90 days after stroke. This study shows that fibrinogen may be a viable target for monitoring and intervention in the management of poststroke neuropsychological and cognitive disorders. Future clinical trials are needed to clarify whether defibrinogenation will prevent or reduce the rate and severity of symptoms of depression, anxiety, and cognitive decline among patients with ischemic stroke.
trial registrationPan African Clinical Trial Registry (registration number: PACTR202406755848901).
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