ArticleCurrent radiopharmaceuticals2025
A New Approach to Synthesize Carbon-11-PBR28 and its Clinical Validation in ALS Patients.
Article in Current radiopharmaceuticals, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionMany studies have reported translocator protein (TSPO) overexpression in various neurological disorders. Carbon-11[
methods[
resultsThe radiochemical purity exceeded 95% with both methods. Using the HPLC-based method, the radiochemical yield was 11.8 ± 3.3%, molar activity was 253 ± 20.9 GBq/μmol, and the total synthesis time of 25 ± 2 minutes. In contrast, the cartridge-based method yielded a radiochemical yield of 53.0 ± 3.6%, a molar activity of 885 ± 17.7 GBq/μmol, and a total synthesis time of 12 ± 2 minutes. In imaging results, higher activity was observed in the precentral gyrus and cerebellum at 2.5 ± 0.5 minutes in bulbar-onset ALS cases, with a standardized uptake value (SUV) of 2.3 ± 0.3. In contrast, limb-onset ALS cases showed the highest uptake at 0.5 ± 0.2 minutes, with an SUV of 1.5 ± 0.2. DISCUSSION: The difference in SUV in bulbar and limb onset may be due to pathological changes.
conclusionThe cartridge-based purification method provided higher radiochemical yield and molar activity as compared to the HPLC purification method.
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