Evidence map›Paper›PMID 40012389›Full record

ArticleCurrent hypertension reviews2025

The Dose-response of Blood Pressure Variability in Stroke and Coronary Heart Disease.

Woro Riyadina, Sulistyowati Tuminah, Lely Indrawati, Nikson Sitorus, Alfons M Letelay, Tri Wurisastuti, Alifa Syamantha Putri, Ika Suswanti, Yuda Turana

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Article in Current hypertension reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Asian expert consensus on high-quality hypertension management.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Woro RiyadinaResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Sulistyowati TuminahResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Lely IndrawatiResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Nikson SitorusResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Alfons M LetelayResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Tri WurisastutiResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Alifa Syamantha PutriResearch Center for Public Health and Nutrition, Organization Research for Health, National Research and Innovation Agency, Center Jakarta, Indonesia.
Ika SuswantiDepartment of Public Health, STIKes Widya Dharma Husada Tangerang, South Tangerang, Banten, Indonesia.
Yuda TuranaDepartment of Neurology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Funding

National Institute of Health Research and Development, Ministry of Health Republic Indonesia 024-11-416176
6 · The paper itself

Abstract

Introduction/ Objective: Blood pressure variability (BPV) is a potential predictor of vascular events and triggers target organ damage. This study aimed to determine the BPV in stroke and coronary heart disease (CHD) in the Bogor Cohort Study in Indonesia.

methodsOver six years of monitoring, a prospective cohort study was conducted on 1649 respondents aged ≥ 31 years from the Bogor Non-communicable Diseases Risk Factors Cohort Study. The dependent variable was vascular events (stroke or CHD), which were new cases (incidents) that appeared during the 6-year monitoring period (2011 - 2017 and 2012-2018).

resultDuring the six years of monitoring, the incidence of vascular events was 12.4 percent. The dose-response of systolic and diastolic BPV in vascular events, stroke, and coronary heart disease showed an increased risk (quintiles Q2, Q3, and Q4) compared to quintile 1 (Q1). Systolic BPV of ≥12,10 mmHg and diastolic BPV of ≥ 7,31 mmHg had a risk of 2.3 and 1.7 (95% Confidence Intervals (CI)), respectively, for vascular events during the period of 6-year observation, after controlling for age, hypertension status, and lipid profile.

conclusionBPV is an independent predictor of vascular events, stroke, and coronary heart disease. The public and clinicians must pay attention to controlling BPV as a risk factor for vascular events, stroke, and CHD.

Indexed as

Blood PressureCoronary DiseaseHypertensionStrokeAdultAgedFemaleHumansIncidenceIndonesiaMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsTime FactorsBlood pressure variabilityBogor cohort study.coronary heart diseasehypertensionnon-communicable diseasesstroke

Identifiers

PMID40012389

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.