ReviewChemical record (New York, N.Y.)2025
Woodward and Hoffmann on Secondary Orbital Interactions. How to Make a Fine Two-Course Meal from Leftovers.
Review in Chemical record (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Creating a Masterpiece. The Road to (and Beyond) Woodward and Hoffmann's 1969 Angewandte Chemie Treatise.Chemical record (New York, N.Y.) · 2026Review
- Woodward and Hoffmann on Secondary Orbital Interactions. How to Make a Fine Two-Course Meal from Leftovers.Chemical record (New York, N.Y.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 1965, R. B. Woodward and Roald Hoffmann published five communications in the Journal of the American Chemical Society that formed the basis for what has been known as the Woodward and Hoffmann (W-H) rules. The last two of these communications applied secondary molecular orbital interactions - that is, interactions that involved atomic orbitals removed from the primary reaction centers - to explain the so-called Alder endo-exo rule of maximum overlap of orbitals for regiochemistry in the Diels-Alder reaction and the then recently noted preference of the chair orientation over the boat orientation in the Cope reaction. This publication presents the back stories of these latter two W-H communications, based on a comprehensive examination of Hoffmann's laboratory notebooks, more than 100 hours of interviews with Hoffmann, interviews with other chemists, and documents found in both Hoffmann's and Woodward's archives.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.