Evidence map›Paper›PMID 40012321›Full record

ArticleCardiology in the young2025

Physical activity and cardiac function in patients with Duchenne muscular dystrophy.

Mary Killian, Jaclyn Tamaroff, Karry Su, Kimberly Crum, Kristen George-Durrett, Larry W Markham, Maciej Buchowski, Thomas Donnelly, W Bryan Burnette, Jonathan H Soslow

Abstract read
In one paragraph

Article in Cardiology in the young, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary KillianDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-6624-1152
Jaclyn TamaroffDivision of Endocrinology, Vanderbilt University Medical Center, Nashville, TN, USA.
Karry SuDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kimberly CrumDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Kristen George-DurrettDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Larry W MarkhamDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Maciej BuchowskiEnergy Balance Laboratory, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Thomas DonnellyDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
W Bryan BurnetteDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jonathan H SoslowDivision of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-9194-5330

Funding

Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug TrialsR01HL167969 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Craig J. Goergen, Kan N Hor · 2024 to 2026
$2.3M
Development of a Multimodal Biomaker Platform for Predictive Risk Stratification of Cardiac Disease in Duchenne Muscular DystrophyR56HL141248 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOSLOW, JONATHAN HARVEY · 2018 to 2018
$769k
FDA HHS R01 FD006649NHLBI NIH HHS R01 HL167969NHLBI NIH HHS R56 HL141248
6 · The paper itself

Abstract

backgroundCardiomyopathy is the leading cause of death in patients with Duchenne muscular dystrophy. The relationship between cardiac and skeletal muscle progression is unclear. The objective of this study was to evaluate the correlation between muscle activity and cardiomyopathy. We hypothesised that cardiomyopathy and skeletal muscle activity are directly related.

methodsPhysical activity was assessed with accelerometers worn for 7 days. Average activity (vector magnitude/min) and percentage of time in different activities were reported. Cardiac MRI was used to assess left ventricular ejection fraction, global circumferential strain (Ecc), late gadolinium enhancement, and cardiac index. Associations were assessed between physical activity and cardiac variables using a Spearman correlation.

resultsDuchenne muscular dystrophy subjects (

conclusionPhysical activity correlates with left ventricular ejection fraction and left ventricular cardiac index and is modified by ambulation. Future analysis should assess the temporal relationship between physical activity and cardiomyopathy.

Indexed as

CardiomyopathiesExerciseMuscular Dystrophy, DuchenneStroke VolumeVentricular Function, LeftAccelerometryAdolescentChildFemaleHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMuscle, SkeletalaccelerometrycardiomyopathyDuchenne muscular dystrophy

Identifiers

PMID40012321
PMCPMC12795471

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.