ArticleAlimentary pharmacology & therapeutics2025
Multicentre Study of 10,369 Symptomatic Patients Comparing the Diagnostic Accuracy of Colon Capsule Endoscopy, Colonoscopy and CT Colonography.
Article in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Patient-Level Predictors of Procedural Success in Colon Capsule Endoscopy: A Systematic Review and Meta-Analysis.Journal of gastroenterology and hepatology · 2026Pooled it
- Second-generation capsule endoscopy for the detection of colorectal polyps: An updated systematic review and comparative meta-analysis of prospective studies.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Pooled it
- Follow-up endoscopy rates as an indicator of effectiveness in colon capsule endoscopy: a systematic review and meta-analysis.BMJ open gastroenterology · 2025Pooled it
- Trial
- Defining post-colon capsule endoscopy colorectal cancer (pCCECRC)-an International Capsule Endoscopy Research (iCARE) group consensus statement.Surgical endoscopy · 2026Article
- Multicenter study of colon capsule endoscopy in post-polypectomy surveillance.Endoscopy international open · 2026Article
- Letter: Assessing the True Filtering Effect of Colon Capsule Endoscopy in Surveillance Cohorts.Endoscopy international open · 2026Article
- Expected Values of Artificial Intelligence in Colon Capsule Endoscopy: Artificial Intelligence in Capsule Endoscopy Consortium Position Statement.Endoscopy international open · 2026Article
- The Role of Video Capsule Endoscopy in Hereditary Polyposis Syndromes: A Narrative Review.Diagnostics (Basel, Switzerland) · 2025Review
- Review
- Patient experience of colon capsule endoscopy in clinical practice: a structured, comparative patient survey.BMJ open gastroenterology · 2025Article
- Article
- Colon Capsule Endoscopy as a Promising Diagnostic Tool in Colorectal Cancer: A Systematic Review and Network Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Factors predicting conversion from colon capsule endoscopy to conventional optical endoscopy-findings from the CESCAIL study.BMC gastroenterology · 2025Article
- The Future of Minimally Invasive GI and Capsule Diagnostics (REFLECT), October 2024.Diagnostics (Basel, Switzerland) · 2025Article
- Colon capsule endoscopy today: Brief overview of leading UK and Danish initiatives.Endoscopy international open · 2025Review
- Patient experiences of colon capsule endoscopy: a qualitative study.Therapeutic advances in gastrointestinal endoscopyArticle
- Optimizing bowel preparation regimens for colon capsule endoscopy: an umbrella review (overview of systematic reviews).Therapeutic advances in gastrointestinal endoscopyArticle
- Marking 25 years of capsule endoscopy: from bold innovation to enduring legacy.Therapeutic advances in gastrointestinal endoscopyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundDuring the COVID-19 pandemic, NHS England introduced colon capsule endoscopy (CCE) at scale to support the recovery of endoscopy. Symptomatic patients referred with suspected colorectal cancer (CRC) and a faecal immunochemical test (FIT) ≤ 100 μg Hb/g faeces were offered CCE.
aimsTo evaluate the safety, diagnostic accuracy and utility of CCE in this setting.
methodsConsenting patients, referred on a suspected CRC pathway with FIT ≤ 100 μg Hb/g faeces, were offered CCE, colonoscopy or CT colonography. Each cohort was to be age-, sex-, symptom- and FIT-matched. We performed a paired comparison of findings in those who required colorectal endoscopy after CCE and recorded clinical outcomes.
resultsWe recruited 4878 patients for CCE, 5025 for colonoscopy and 466 for CT colonography patients. CCE was safely tolerated by 98.4% of patients. CCE identified a matched mass lesion in all patients with CRC when the examination was complete and adequately prepared. More polyps ≥ 10 mm and 6-9 mm were detected by CCE than by colonoscopy or CT colonography. Per-patient sensitivities for polyps ≥ 10 mm and 6-9 mm were 97% in those with a paired, complete and adequately prepared CCE than colonoscopy. Completion (74%) and bowel preparation adequacy rates (74%) were poorer than those of colonoscopy and CTC (both 88%). However, CCE usefully performed a filter function in 86% of patients.
conclusionsCCE is safe and accurate for the diagnosis of colorectal disease. In the suspected CRC pathway, its 'filter function' complements existing colorectal diagnostic services by creating additional capacity.
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