Evidence map›Paper›PMID 40012220›Full record

ArticleJournal of cellular and molecular medicine2025

Vitamin C Mediates IGFBP7 to Alleviate Chronic Atrophic Gastritis via the HIF-1α/VEGF Pathway.

Xun Cheng, Hao Gu, Yulin Chong, Fan Li, Songhua Bei, Huanqing Li, Jun Jiang, Ming Pan, Li Feng, Xiaohong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xun ChengEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Hao GuEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Yulin ChongEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Fan LiEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Songhua BeiEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Huanqing LiEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Jun JiangEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.
Ming PanDepartment of Traditional Chinese Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Li FengEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.ORCID 0009-0009-7755-0805
Xiaohong ZhangEndoscopy Center, Minhang Hospital, Fudan University, Shanghai, China.ORCID 0009-0009-4813-8694

Funding

Minhang District Medical Education and Research Collaborative Health Service System 2024MZYS16
6 · The paper itself

Abstract

Chronic atrophic gastritis (CAG) is a precancerous lesion characterised by gastric mucosal atrophy and inflammation. Identifying key molecular mechanisms and potential therapeutic targets is essential to improve patient outcomes. Key modules and differentially expressed genes (DEGs) were recognised in the GSE153224 dataset using weighted gene co-expression network analysis (WGCNA) and examination of differential expression. IGFBP7 was identified as a hub gene by protein-protein interaction (PPI) network and expression validation. CAG patients' blood parameters and gastric mucosal health status were evaluated before and after the treatment of vitamin C (VC). In addition, we investigated the effects of VC and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on GES-1 cells, including cell viability, apoptosis and the expression of inflammatory and angiogenic markers. WGCNA identified that the blue module was significantly associated with CAG with a correlation coefficient 0.924. Among 93 overlapping genes, IGFBP7 was notably underexpressed and selected as a hub gene. ROC analysis confirmed the high diagnostic performance of IGFBP7. CAG patients treated with VC showed significant improvement in blood parameters and improved gastric mucosal health. In vitro, VC increased cell viability, reduced cytotoxicity and apoptosis and lowered COX-2 and apoptosis-related protein expression in MNNG-treated GES-1 cells. Knockdown of IGFBP7 further influenced these effects. MNNG upregulated HIF-1α/VEGF signalling proteins, which VC attenuated. Combined VC and IGFBP7 knockdown showed potential protective effects. This study highlights the regulatory role of VC and IGFBP7 in CAG and demonstrates their potential as therapeutic targets for improving gastric mucosal health and mitigating inflammation.

Indexed as

Ascorbic AcidGastritis, AtrophicHypoxia-Inducible Factor 1, alpha SubunitInsulin-Like Growth Factor Binding ProteinsSignal TransductionVascular Endothelial Growth Factor AApoptosisCell LineChronic DiseaseGastric MucosaGene Expression RegulationGene Regulatory NetworksHumansMaleProtein Interaction MapsAscorbic AcidHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunitinsulin-like growth factor binding protein-related protein 1Insulin-Like Growth Factor Binding ProteinsVascular Endothelial Growth Factor AVEGFA protein, humanchronic atrophic gastritisHIF‐1α/VEGF signalling pathwayIGFBP7N‐methyl‐N′‐nitro‐N‐nitroso‐guanidinevitamin C

Identifiers

PMID40012220
PMCPMC11865351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.