Evidence map›Paper›PMID 40012199›Full record

ArticleThe Journal of physiology2025

Acute exogenous oestradiol augments endothelial and smooth muscle vasodilatory responsiveness in premenopausal but not postmenopausal females.

Gabrielle A Dillon, Ronée E Harvey, Jacqueline K Limberg, Wayne T Nicholson, Michael J Joyner, Sarah E Baker, Virginia M Miller, Sushant M Ranadive

Abstract read
In one paragraph

Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gabrielle A DillonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-5365-2852
Ronée E HarveyDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-8861-5477
Jacqueline K LimbergDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9982-5851
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3418-4253
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-7135-7643
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-9647-7660
Virginia M MillerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Sushant M RanadiveDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Hot Flashes and Neurovascular Function in WomenK01HL148144 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2021 to 2025
$867k
American Heart Association-American Stroke Association AHA_898679NCATS NIH HHS UL1 TR000135NHLBI NIH HHS K01 HL148144NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

Menopause is associated with vascular dysfunction. During the menopausal transition, endogenous oestradiol concentrations diminish. Oestradiol is vasoprotective because it has direct and indirect effects on the vasculature. The present study aimed to determine the effect of acute exogenous oestradiol on endothelium-dependent, endothelium independent and β

Indexed as

Endothelium, VascularEstradiolMuscle, Smooth, VascularPostmenopausePremenopauseVasodilationAcetylcholineAdultFemaleForearmHumansMiddle AgedNitroprussideTerbutalineVasodilator AgentsAcetylcholineEstradiolNitroprussideTerbutalineVasodilator Agentsendotheliummenopausemicrovascularwomen

Identifiers

PMID40012199
PMCPMC12013789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.