SynthesisJournal of perioperative practice
Association of polypharmacy and perioperative outcomes: Systematic review and meta-analysis.
Synthesis in Journal of perioperative practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Predictive Utility of Epic's Health Composite Score for Same-Day Cancellation in Cataract Surgery.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Retrospective multi-centre cohort study of polypharmacy, the Drug Burden Index and associations with outcomes in older surgical inpatients.Age and ageing · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polypharmacy is becoming more prevalent due to an ageing population. As more patients are undergoing surgical procedures, it is important to determine which group of patients are at higher risk of poorer outcomes. This review aimed to provide a summary of existing literature and to determine if polypharmacy is associated with poorer perioperative outcomes and to identify any gaps in the literature. This systematic review was conducted using electronic databases PubMed, Embase and Web of Science from their inception to December 2024. Statistical analysis was performed using generic inverse variance method. We identified 45 eligible studies from different countries and different surgical populations. Thirty-two studies (71.11%) defined polypharmacy as the use of five or more medications. Polypharmacy is significantly associated with postoperative delirium (odds ratio = 1.62, 95% confidence interval = 1.32-1.98,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.