Acute subanesthetic ketamine-induced effects on the mismatch negativity and their relationship to early and sustained treatment response in major depressive disorder.

Sara de la Salle, Jennifer L Phillips, Pierre Blier, Verner Knott

Abstract readClinical Trial, Phase IClinical Trial, Phase IIClinical Trial, Phase III

In one paragraph

Trial report in Journal of psychopharmacology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Altered theta oscillations in basolateral amygdala and ventral hippocampus related to social defeat.BMC neuroscience · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara de la SalleUniversity of Ottawa Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.ORCID 0000-0002-1698-5938

Jennifer L PhillipsUniversity of Ottawa Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.ORCID 0000-0001-9635-8602

Pierre BlierUniversity of Ottawa Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.

Verner KnottUniversity of Ottawa Institute of Mental Health Research at the Royal, Ottawa, ON, Canada.ORCID 0000-0002-4969-3819

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA sub-anesthetic dose of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, produces robust antidepressant effects in treatment-resistant major depressive disorder (MDD). The mismatch negativity (MMN) is reliant on glutamatergic neurotransmission and reduced by NMDAR antagonists. The MMN may characterise the neural mechanisms underlying ketamine's effects.

aimsThis study examined the acute effects of ketamine and midazolam on the MMN and its relationship to early and sustained decreases in depressive symptoms.

methodsTreatment-resistant MDD patients (

resultsKetamine reduced frontal MMN amplitudes, theta ERO immediately post- and 2 h post-infusion and source-localised peak MMN frontal generator activity. Select baseline and ketamine-induced MMN decreases correlated and predicted greater early (left frontal MMN decreases in amplitude and theta ERO, baseline left PLF) and sustained (baseline left PLF, right inferior temporal activity) symptom reductions.

conclusionsAcute NMDARs blockade reduced frontal MMN, with larger MMN reductions predicting greater symptom improvement. The MMN may serve as a non-invasive biomarker predicting antidepressant response to glutamatergic agents.

Indexed as

Antidepressive AgentsDepressive Disorder, Treatment-ResistantKetamineMajor Depressive DisorderAdultCross-Over StudiesDouble-Blind MethodElectroencephalographyExcitatory Amino Acid AntagonistsFemaleHumansInfusions, IntravenousMaleMidazolamMiddle AgedReceptors, N-Methyl-D-AspartateAntidepressive AgentsExcitatory Amino Acid AntagonistsKetamineMidazolamReceptors, N-Methyl-D-Aspartatecortical source densityevent-related oscillationsketamineMajor depressive disordermidazolammismatch negativitytreatment response

Identifiers

PMID40012166

DOI10.1177/02698811251319456

PMCPMC12205165

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.