SynthesisBMC pregnancy and childbirth2025
Fetal brain development in fetal growth restriction using MRI: a systematic review.
Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Intranasal stem cell treatment ameliorates neuroinflammation and myelin aberrations in fetal growth-restricted rat pups.Stem cells translational medicine · 2026Article
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Evaluation of fetal brain development in growth restriction subtypes using brain MRI volume measurement.BMC pregnancy and childbirth · 2026Article
- The Contribution of Ultrasound and Doppler Studies on Impaired Intrauterine Conditions and the Development of Future Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Advances in automated fetal brain MRI segmentation and biometry: Insights from the FeTA 2024 challenge.Medical image analysis · 2026Article
- The Sooner, the Better: Neuroprotective Strategies in Fetuses With Congenital Heart Disease.Prenatal diagnosis · 2026Review
- Quantitative assessment of brain sparing effect in fetal growth restriction: structural evidence from fetal MRI.Frontiers in neuroscience · 2026Article
- The Effect of Ferulic Acid on the Akt-GSK3β Signaling Pathway, Neuroinflammation, Oxidative Stress, and Cortical Damage in the Fetal Brain with Uteroplacental Insufficiency.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Fetal MRI study of brain differences in early-onset fetal growth restriction versus healthy controls at 30 weeks of gestation.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Neonatal brain MRI to prognosticate neurodevelopmental outcomes in fetal growth restricted infants: a systematic review.Frontiers in pediatrics · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review investigates potential differences in brain development between growth restricted (FGR)-fetuses compared to appropriate for gestational age (AGA) fetuses using MRI.
methodsPubMed, Embase, Cochrane Library and Web of Science databases were searched from 1985 to 2023. FGR was defined as an estimated fetal weight (EFW) < p10 and/or an abdominal circumference (AC) < p10, or 20% reduction in EFW or AC using a minimum interval of two weeks. Outcomes included volumetrics, biometrics, apparent diffusion coefficients (ADC),
resultsTwenty-nine studies were included after three-phase screening, 13 used the FGR consensus definition according to the Delphi procedure. Total brain volume and cerebellar volume were significantly reduced in FGR fetuses (n = 183; 74) when compared to AGA fetuses (n = 283; 166) with a MD of -30.84 cm DISCUSSION: MRI provides additional information on fetal brain development in a growth restricted population. Smaller total brain and cerebellar volumes and lower ADC values in the FWM, OWM, TWM, thalami, CSO, basal ganglia, pons and cerebellum have been observed in FGR. These conclusions are drawn on relatively small sample sizes with high heterogeneity resulting from diverse study populations and MRI techniques. Furthermore, how these findings correlate to long-term neurocognitive abnormalities associated with FGR remains to be elucidated. A large cohort study comparing brain maturation, myelination, metabolic and hemodynamic status between brain-sparing FGR fetuses to healthy age-matched controls is needed.
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