ArticleReproductive biology and endocrinology : RB&E2025
Effects of SARS-CoV-2 infection during IVF treatment on embryo morphokinetics and pregnancy outcomes after fresh transfer: a prospective cohort study.
Article in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The impact of COVID-19 infection on the live birth rate in fresh embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Impact of COVID-19 infection on laboratory and clinical outcomes of ovarian stimulation using antagonist protocol.Frontiers in medicine · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivesPrior studies have assessed the association between SARS-CoV-2 convalescence and subsequent in vitro fertilization (IVF) treatment, while the outcomes of couples infected during controlled ovarian stimulation (COS) were limited and controversial. The aim of this study was to clarify the effects of SARS-CoV-2 infection during COS on embryo morphokinetics and IVF clinical outcomes with the use of time-lapse monitoring.
methodsWe conducted a prospective cohort study of 230 couples who underwent IVF cycles between April 2023 and April 2024 in an academic fertility center. Participants were divided into four groups based on the nucleic acid testing for SARS-CoV-2 during COS: both positive (n = 31), female positive (n = 64), male positive (n = 20), and both negative (n = 115). A time-lapse imaging system was used for embryo culture. Multivariate logistic regression and generalized linear models were performed to control for potential confounders.
resultsCompared with the both negative group, the both positive group had a significantly lower cleavage rate (97.4 ± 7.7% vs. 93.6 ± 11.5%; β
conclusionSARS-CoV-2 infection in both partners affects morphokinetic parameters of embryo development with decreased cleavage rate and blastocyst formation rate, but does not influence pregnancy and neonatal outcomes after fresh embryo transfer. Our study implies that reproductive physicians should pay attention to infertile couples with SARS-CoV-2 infection during IVF treatment and should provide adequate counseling on their embryo and pregnancy outcomes.
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