ArticleBMC complementary medicine and therapies2025
Protective effects of cedrol against transient global cerebral ischemia/reperfusion injury in rat.
Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Blockade of the SP/NK1 receptor axis: multimodal neuroprotection via inflammatory suppression, hypoxic modulation, and lympho-vascular remodeling in global cerebral ischemia.Metabolic brain disease · 2026Article
- 3',4'-Dihydroxyflavonol has a positive effect on the cerebellum oxidant/antioxidant system and BDNF and transmitter levels in focal brain ischemia-reperfusion.Journal of bioenergetics and biomembranes · 2026Article
- A Review of the Anticancer Properties of Cedrol and its Molecular Mechanisms.Anti-cancer agents in medicinal chemistry · 2026Review
- Biochemical assessment of selenium's cardiovascular protective effects in a lipopolysaccharide-induced damage in rats: Focus on oxidative stress markers and IL-6.Journal of cardiovascular and thoracic research · 2025Article
- Anti-Inflammatory and Antifungal Activities of Wood Essential Oil fromPlants (Basel, Switzerland) · 2025Article
- Review
- Neuroprotective effect of cedrol in a male rat model of Parkinson's disease.Physiological reports · 2025Article
- Effects of inhalingFrontiers in psychology · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe natural compound cedrol possess anti-inflammatory and antioxidant properties. We sought to assess the neuroprotective effect of cedrol in an animal model of transient global ischemia/reperfusion (I/R) injury.
methodTo induce transient global cerebral I/R injury, bilateral carotid arteries were temporarily occluded for 20 min. A total of 40 male Wistar rats were randomly divided in to 5 groups; The control and global I/R groups, and the treatment groups that received cedrol at doses of 7.5, 15, and 30 mg/kg/day for a week, following the global I/R induction. The passive avoidance test was used for assessing memory function, and then hippocampal tissues were collected to assess levels of malondialdehyde (MDA), total thiol, nitric oxide (NO), and the activity of superoxide dismutase (SOD), along with the concentration of brain-derived neurotrophic factor (BDNF).
resultOur findings revealed that global I/R injury impaired rats' performance in the passive avoidance test and increased levels of MDA and NO. Moreover, it decreased the total thiol level, SOD activity, and BDNF level in the hippocampus. Administration of cedrol significantly improved memory function, reduced oxidative stress, NO level and increased BDNF level in the hippocampus.
conclusionThe results indicate that cedrol has neuroprotective properties in global I/R by reducing oxidative stress and enhancing the levels of BDNF.
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