Evidence map›Paper›PMID 40012038›Full record

ArticleCell communication and signaling : CCS2025

Regulation of CXCR4 function by S1P

Hyun-Tae Kim, Jae-Yeon Jeong, Won-Ki Huh

Abstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hyun-Tae KimSchool of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Jae-Yeon JeongGPCR Therapeutics Inc, Gwanak-gu, Seoul, 08790, Republic of Korea. jeongjy@gpcr.co.kr.
Won-Ki HuhSchool of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea. wkh@snu.ac.kr.

Funding

National Research Foundation of Korea 2020R1A5A1018081
6 · The paper itself

Abstract

backgroundThe trafficking of immune cells between lymphoid organs and circulation depends on gradients of CXCL12 and sphingosine-1-phosphate (S1P), mediated through their cognate receptors C-X-C chemokine receptor type 4 (CXCR4) and S1P receptor type 1 (S1P

methodsBimolecular fluorescence complementation (BiFC) assay, proximity ligation assay (PLA), and quantitative bioluminescence resonance energy transfer (BRET) assay were employed to detect CXCR4-S1P

resultsCXCR4-S1P

conclusionsThis study identifies CXCR4-S1P

Indexed as

Protein MultimerizationReceptors, CXCR4Cell MovementChemokine CXCL12HEK293 CellsHumansJurkat CellsLysophospholipidsSignal TransductionSphingosineSphingosine-1-Phosphate ReceptorsChemokine CXCL12CXCR4 protein, humanLysophospholipidsReceptors, CXCR4Sphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsCXCR4G protein-coupled receptorHeteromerS1P1

Identifiers

PMID40012038
PMCPMC11863771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.