Evidence map›Paper›PMID 40011909›Full record

ArticleBMC veterinary research2025

A comparative proteomic-based study identifies essential factors involved in hair follicle growth in inner Mongolia cashmere goats.

Rile Nai, Chongyan Zhang, Yuchun Xie, Duhu Man, Haijun Li, Lina Ma, Lu Mi, Meng Zhao, Qier Mu, Lixia Gao and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rile Nai *College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Chongyan Zhang *College of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Yuchun Xie *College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, 066004, China.
Duhu ManCollege of Agriculture, Hulunbuir University, Hulunbuir, 021008, China.
Haijun LiCollege of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Lina MaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Lu MiCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Meng ZhaoInner Mongolia Academy of Agriculture and Animal Husbandry Sciences, Hohhot, 010018, China.
Qier MuCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China.
Lixia GaoBaotou Light Industry Vocational Technical College, Baotou, 014035, China.
Zhihong LiuCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China. liuzh7799@163.com.
Jinquan LiCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot, 010018, China. lijinquan_nd@126.com.

Funding

Doctoral Fund Project of Hulunbuir College 2020BS12Inner Mongolia Education Department Special Research Project For First Class Disciplines YLXKZX-NND-007Northern Agriculture and Livestock Husbandry Technology Innovation Center BFGJ2022002Science and Technology Plan of Inner Mongolia Autonomous Region 2023KYPT0021the National Key R&D Program of China 2021YFD200901University Youth Science and Technology Talent Support Project of Inner Mongolia Autonomous Region NJYT23012
6 · The paper itself

Abstract

Renowned for its invaluable undercoat, the cashmere goat is well known. The growth of cashmere fibre initiates when the relatively inactive telogen stage transitions to the anagen stage, which involves active proliferation. However, the molecular mechanisms responsible for this process are still unclear. Here, SWATH mass spectrometry (MS), a comparative proteomic analysis, was conducted to examine the proteomic alterations in Inner Mongolia cashmere goat skin samples at two different developmental stages (anagen and telogen). In total, 2414 proteins were detected, with 631 proteins showing differential regulation (503 upregulated proteins and 128 downregulated proteins). Bioinformatic analysis revealed that these proteins, which are differentially regulated, play crucial roles in the pathways associated with metabolism and fatty acids according to the GO and KEGG analyses. Furthermore, interactome analysis revealed that differentially regulated keratins have a crucial impact. The localization of KRT25, KRT71, and KRT82 using immunohistochemistry revealed that these proteins were expressed in the secondary hair follicles of cashmere goat skin. The keratin family plays an irreplaceable and important role in the process of hair follicle growth.

Indexed as

GoatsHair FollicleProteomeAnimalsKeratinsProteomicsKeratinsProteomeAnagenCashmere goatHair follicleProteomicsTelogen

Identifiers

PMID40011909
PMCPMC11866830

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.