Trial reportBMC oral health2025
The short-term effects of full-mouth or quadrant-wise applied subgingival instrumentation on immune response and oxidation process in saliva: a randomized clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate oxidation and antioxidant activity in the saliva of periodontitis patients following non-surgical periodontal therapy applied either as full mouth subgingival instrumentation (FM) or quadrantwise (Q).
methodsPatients affected by periodontitis were randomly allocated to receive FM or Q and followed up at 1st and 3rd months. Saliva samples and periodontal variables were collected at baseline, 1st, and 3rd month. The primary outcomes were the total antioxidant status (TAS), total oxidant status (TOS). Secondary outcomes were clinical measurements, Tumour Necrosis Factor alpha (TNF alpha), and Oxidative Stress Index (OSI) parameters.
resultsForty-five subjects were included in the study. Both FM and Q resulted reductions in all periodontal variables, TNF alpha and TOS values, with an improvement in TAS values compared to baseline. Significant differences were observed in the reductions of probing pocket depth (PPD) and clinical attachment level (CAL) between the FM group and the Q group as periodontal variables (p < 0.05). The change in TNF alpha (ng/L) and TAS (mmol Trolox Eq/L) from baseline to post treatment significantly improved in FM group compared to Q.
conclusionBoth treatment protocols were efficient in the treatment of periodontitis but the FM therapy significantly reduced periodontal tissue inflammation, as evidenced by changes in both clinical and biochemical parameters in our study. However, it may be seen that FM therapy is more effective during short-term recovery, maybe the reason could be attributed to TAS and TNF alpha changes following FM therapy.
trial registrationThis study was registered at Thai Clinical Trials Registry. ( https://www.thaiclinicaltrials.org/show/TCTR20240416007 , TCTR ID: TCTR20240416007; date of registration: 16 April 2024)-retrospectively registered).
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