Evidence map›Paper›PMID 40011840›Full record

ArticleBMC pregnancy and childbirth2025

Maternal and fetal survival following Ebola, HIV and Malaria co-infection in the first trimester of gestation in resource-limited setting in Democratic Republic of Congo.

Prince Imani-Musimwa, Emilie Grant, Daniel Mukadi-Bamuleka, Zacharie Tsongo-Kibendelwa, Rigo Fraterne-Muhayangabo, Placide Mbala-Kingebeni, Richard Kitenge-Omasumbu, Olivier Nyakio-Ngeleza, Théophile Barhwamire-Kabesha, Minos Minani-Ndabahweje and 4 more

Abstract readCase Reports
In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Prince Imani-MusimwaDepartment of Obstetrics and Gynecology, School of Medicine, University of Goma, Goma, Democratic Republic of Congo. princeimani12@gmail.com.ORCID https://orcid.org/0000-0003-3507-8388
Emilie GrantCentre Régional d'Expertise en Recherche et Actions Humanitaires (CIERAH-Africa), Goma, Democratic Republic of Congo.ORCID https://orcid.org/0009-0009-0074-7538
Daniel Mukadi-BamulekaInstitut National de Recherche Bio-Médicale (INRB), Kinshasa, Democratic Republic of Congo.ORCID https://orcid.org/0000-0002-6836-8704
Zacharie Tsongo-KibendelwaSchool of Public Health, University of Goma, Goma, Democratic Republic of Congo.
Rigo Fraterne-MuhayangaboCentre Régional d'Expertise en Recherche et Actions Humanitaires (CIERAH-Africa), Goma, Democratic Republic of Congo.ORCID https://orcid.org/0000-0002-3266-0252
Placide Mbala-KingebeniDepartment of Medical Biology, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.ORCID https://orcid.org/0000-0003-1556-3570
Richard Kitenge-OmasumbuMinistry of Public Health, Hygiene and Prevention, Kinshasa, Democratic Republic of Congo.
Olivier Nyakio-NgelezaDepartment of Obstetrics and Gynecology, School of Medicine, Official University of Bukavu, Bukavu, Democratic Republic of Congo.
Théophile Barhwamire-KabeshaDepartment of Surgery, School of Medicine, Official University of Bukavu, Bukavu, Democratic Republic of Congo.
Minos Minani-NdabahwejeDepartment of Internal Medicine, School of Medicine, University of Goma, Goma, Democratic Republic of Congo.
Juakali Sihali-KyolovDepartment of Obstetrics and Gynecology, School of Medicine, University of Kisangani, Kisangani, Democratic Republic of Congo.
Richard Bitwe-MihandaSchool of Public Health, University of Goma, Goma, Democratic Republic of Congo.ORCID https://orcid.org/0009-0004-6409-6299
Dieudonné Sengeyi-Mushengezi-AmaniDepartment of Obstetrics and Gynecology, School of Medicine, University of Kinshasa, Kinshasa, Democratic Republic of Congo.ORCID https://orcid.org/0000-0002-7197-8159
Mija VerversCenter for Humanitarian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.ORCID https://orcid.org/0000-0002-7182-2998

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEbola-HIV and malaria co-infection is one of the rare clinical situations that remains complex to manage even in the context of unlimited resources. In pregnancy, each of these infections can compromise maternal and fetal outcomes. The synergy of their effects on maternal immunity are often fatal, and survival is an exception, especially in a context of limited resources, such as in Ebola Treatment Units (ETUs). CASE PRESENTATION: Our 22-year-old patient, weighing 56 kg and nine weeks pregnant was admitted to the ETU during the 10th outbreak in DRC. She had HIV and had abandoned antiretroviral treatment (ART) seven months before. One month before her admission, her HIV viral load was high with a low CD4

conclusionIn case of Ebola, HIV and malaria co-infection, maternal and fetal survival remains possible even in the context of resources limited-setting. This case raises questions about the effects of the interactions of these co-infections and/or their antibodies, treatment during immune adaptation of the gravid organism.

Indexed as

CoinfectionHemorrhagic Fever, EbolaHIV InfectionsMalariaPregnancy Complications, InfectiousDemocratic Republic of the CongoFemaleHumansInfant, NewbornPregnancyPregnancy Trimester, FirstResource-Limited SettingsViral LoadYoung AdultAntiretroviral treatmentEbola-HIV and Malaria co-infectionImmune cell tropismMaternal and fetal survivalMonoclonal therapyPregnancyRD CongoResource-limited setting

Identifiers

PMID40011840
PMCPMC11863912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.