Evidence map›Paper›PMID 40011787›Full record

ArticleNature2025

Systems-level design principles of metabolic rewiring in an animal.

Xuhang Li, Hefei Zhang, Thomas Hodder, Wen Wang, Chad L Myers, L Safak Yilmaz, Albertha J M Walhout

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Glycolytic Specialization Shapes Neuronal Physiology and FunctionbioRxiv : the preprint server for biology · 2026
    Article
  7. Harnessing microalgae for bioproducts: innovations in synthetic biology.World journal of microbiology & biotechnology · 2025
    Review
  8. Article
  9. Review
  10. Glycogen supports glycolytic plasticity in neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuhang Li *Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-6071-9605
Hefei Zhang *Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-5187-7166
Thomas HodderGraduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA.
Wen WangDepartment of Computer Science and Engineering, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-5812-6744
Chad L MyersGraduate Program in Bioinformatics and Computational Biology (BICB), University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0002-1026-5972
L Safak YilmazDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Albertha J M WalhoutDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. marian.walhout@umassmed.edu.ORCID 0000-0001-5587-3608

Funding

Transcription networks in C elegans organogenesisR01DK068429 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI A. J. Marian Walhout · 2005 to 2026
$10.9M
Gene regulatory and metabolic network structure, function and evolutionR35GM122502 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI A. J. Marian Walhout · 2017 to 2026
$8.3M
NIDDK NIH HHS R01 DK068429NIGMS NIH HHS R35 GM122502
6 · The paper itself

Abstract

The regulation of metabolism is vital to any organism and can be achieved by transcriptionally activating or repressing metabolic genes

Indexed as

Caenorhabditis elegansGene Regulatory NetworksMetabolic Networks and PathwaysModels, BiologicalSystems BiologyAnimalsBiomassEnergy MetabolismGene Expression RegulationRNA InterferenceTranscription, Genetic

Identifiers

PMID40011787
PMCPMC13019327

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.