Evidence map›Paper›PMID 40011781›Full record

ArticleNature2025

Brain-wide presynaptic networks of functionally distinct cortical neurons.

Ana R Inácio, Ka Chun Lam, Yuan Zhao, Francisco Pereira, Charles R Gerfen, Soohyun Lee

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
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  7. Article
  8. Brainwide blood volume reflects opposing neural populations.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana R InácioUnit on Functional Neural Circuits, Systems Neurodevelopment Laboratory, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. ana.inacio@nih.gov.ORCID 0000-0002-8431-9515
Ka Chun Lam *Machine Learning Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-2131-4386
Yuan Zhao *Machine Learning Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6123-8579
Francisco PereiraMachine Learning Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Charles R GerfenSection on Neuroanatomy, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9008-4882
Soohyun LeeUnit on Functional Neural Circuits, Systems Neurodevelopment Laboratory, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. soohyun.lee@nih.gov.ORCID 0000-0003-1532-7041

Funding

Functional Organization Of The Cerebral Cortex and Basal GangliaZIAMH002497 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI GERFEN, CHARLES R · 2009 to 2025
$18.3M
Machine Learning TeamZICMH002968 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PEREIRA, FRANCISCO · 2018 to 2025
$13.9M
Circuit mechanisms underlying cortical communicationsZIAMH002959 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEE, SOOHYUN · 2017 to 2025
$13.7M
Intramural NIH HHS ZIA MH002497Intramural NIH HHS ZIA MH002959Intramural NIH HHS ZIC MH002968
6 · The paper itself

Abstract

Revealing the connectivity of functionally identified individual neurons is necessary to understand how activity patterns emerge and support behaviour. Yet the brain-wide presynaptic wiring rules that lay the foundation for the functional selectivity of individual neurons remain largely unexplored. Cortical neurons, even in primary sensory cortex, are heterogeneous in their selectivity, not only to sensory stimuli but also to multiple aspects of behaviour. Here, to investigate presynaptic connectivity rules underlying the selectivity of pyramidal neurons to behavioural state

Indexed as

Nerve NetNeuronsPresynaptic TerminalsSomatosensory CortexAnimalsBehavior, AnimalCalciumFemaleGlutamic AcidMaleMiceMotor CortexOptogeneticsPyramidal CellsSingle-Cell AnalysisCalciumGlutamic Acid

Identifiers

PMID40011781
PMCPMC12043506

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.