Evidence map›Paper›PMID 40011778›Full record

ArticleNature2025

Extensive mutual influences of SMC complexes shape 3D genome folding.

Han Zhao, Lirong Shu, Shiyi Qin, Fangxuan Lyu, Fuhai Liu, En Lin, Sijian Xia, Baiyue Wang, Manzhu Wang, Fengnian Shan and 6 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
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  11. Review
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  13. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Han Zhao *Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Lirong Shu *Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.ORCID 0000-0002-2766-9586
Shiyi Qin *Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Fangxuan LyuInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China.
Fuhai LiuInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
En LinInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Sijian XiaInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Baiyue WangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Manzhu WangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Fengnian ShanInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Yinzhi LinInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Lin ZhangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Yufei GuInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China.
Gerd A BlobelDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-0714-9612
Kai HuangInstitute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, China. huangkai@szbl.ac.cn.ORCID 0000-0001-8400-9341
Haoyue ZhangInstitute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, China. zhang_adam@szbl.ac.cn.ORCID 0009-0008-9927-6723

Funding

Transcriptional Networks Controlling Erythroid DifferentiationR01DK054937 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 1999 to 2026
$12.8M
NIDDK NIH HHS R01 DK054937
6 · The paper itself

Abstract

Mammalian genomes are folded through the distinct actions of structural maintenance of chromosome (SMC) complexes, which include the chromatin loop-extruding cohesin (extrusive cohesin), the sister chromatid cohesive cohesin and the mitotic chromosome-associated condensins

Indexed as

Cell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosomesCohesinsGenomeMultiprotein ComplexesAdenosine TriphosphatasesAnimalsCCCTC-Binding FactorCell LineChromatidsChromatinChromosome StructuresDNA-Binding ProteinsHumansInterphaseAdenosine TriphosphatasesCCCTC-Binding FactorCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneCohesinscondensin complexesDNA-Binding ProteinsMultiprotein Complexes

Identifiers

PMID40011778
PMCPMC12726995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.