Evidence map›Paper›PMID 40011768›Full record

ArticleNature2025

A hypothalamic circuit underlying the dynamic control of social homeostasis.

Ding Liu, Mostafizur Rahman, Autumn Johnson, Ryunosuke Amo, Iku Tsutsui-Kimura, Zuri A Sullivan, Nicolai Pena, Mustafa Talay, Brandon L Logeman, Samantha Finkbeiner and 8 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Astrocytes mediate a positive feedback loop for oxytocin.bioRxiv : the preprint server for biology · 2026
    Article
  14. Review
  15. Susceptibility of Glucose Regulation to Social Isolation.bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Brain-immune interactions generate pathogen-specific sickness states.bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ding LiuDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Mostafizur RahmanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Autumn JohnsonDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0009-0004-7527-6666
Ryunosuke AmoDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-8644-2296
Iku Tsutsui-KimuraDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7554-4764
Zuri A SullivanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Nicolai PenaDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Mustafa TalayDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9046-1366
Brandon L LogemanDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9975-3541
Samantha FinkbeinerDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Lechen QianDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-6767-9773
Seungwon ChoiDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.
Athena Capo-BattagliaDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Ishmail Abdus-SaboorDepartment of Biological Sciences, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
David D GintyDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9723-8530
Naoshige UchidaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-5755-9409
Mitsuko Watabe-UchidaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-7864-754X
Catherine DulacDepartment of Molecular and Cellular Biology, Howard Hughes Medical Institute, Center for Brain Science, Harvard University, Cambridge, MA, USA. dulac@fas.harvard.edu.ORCID 0000-0001-5024-5418

Funding

Systems-level and in situ transcriptomics deconstruction of neural circuits underlying sensorimotor transformation in an innate behaviorRF1NS116593 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE, MURTHY, VENKATESH N · 2020 to 2020
$4.4M
Systems-Level and in Situ Transcriptomics Deconstruction of Neural Circuits Underlying Sensorimotor Transformation in an Innate BehaviorR01NS116593 · NINDS · HARVARD UNIVERSITY · PI DULAC, CATHERINE, MURTHY, VENKATESH N · 2023 to 2024
$2.7M
Basal ganglia circuit mechanisms for threat copingR01MH133950 · NIMH · HARVARD UNIVERSITY · PI UCHIDA, NAOSHIGE, WATABE-UCHIDA, MITSUKO · 2023 to 2025
$2.0M
Sex and physiological State dependent molecular characterization of circuits governing parental behaviorR00HD108801 · NICHD · UNIVERSITY OF KENTUCKY · PI Brandon Logeman · 2025 to 2026
$473k
NICHD NIH HHS R00 HD108801NIMH NIH HHS R01 MH133950NINDS NIH HHS R01 NS116593NINDS NIH HHS RF1 NS116593
6 · The paper itself

Abstract

Social grouping increases survival in many species, including humans

Indexed as

HypothalamusNeural PathwaysSocial BehaviorSocial IsolationAnimalsFemaleHomeostasisMaleMiceMice, Inbred C57BLNeuronsPreoptic AreaRewardTouch

Identifiers

PMID40011768
PMCPMC12018270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.