ArticleNature2025
Glycocalyx dysregulation impairs blood-brain barrier in ageing and disease.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
82 citing papers in PubMed.
- Glycosylation in gut-brain communication: from the intestinal barrier and microbiota to immune and neural signaling.Gut microbes · 2026Review
- Ellagitannin Metabolite Urolithin D Ameliorates Cognitive Function and Behavioral Performance in Aging Mice Partially via AMPK/PGC-1α/SIRT3-Dependent Regulation of Mitophagy-Related Molecular Machinery.Molecular neurobiology · 2026Article
- Profiling extracellular vesicle glycoRNAs defines their function in vesicular communication.Nature structural & molecular biology · 2026Article
- Vascular aging as a driver of organ dysfunction and systemic aging.Nature cardiovascular research · 2026Review
- VINE-seq and MultiVINE-seq for single-nucleus and multiome profiling of the brain vasculature.Nature protocols · 2026Review
- Advances in Living Cell-Mediated Nanodrug Delivery Systems: Construction Strategies, Applications and Challenges.Pharmaceutics · 2026Review
- A biomimetic glycosylated peptide sensor with enhanced assaying accuracy in complex biofluids.Chemical science · 2026Article
- Evaluating the endothelial glycocalyx from bench to bedside: a translational framework for microvascular assessment.Angiogenesis · 2026Review
- Opposing roles for lipocalins and a CD36 family scavenger receptor in apical extracellular matrix-dependent protection of narrow tube integrity.Development (Cambridge, England) · 2026Article
- Glycation at the Gate: A Brain Endothelial Glycocalyx Model and Therapeutic Roadmap for Alzheimer's Disease.Biomedicines · 2026Article
- Beyond the sugar coating: mucin-type O-Glycosylation as an underappreciated player in brain function and disease.Molecular psychiatry · 2026Review
- RNF213 in Panvascular Disease: A Molecular Hub Linking Genetic Susceptibility to Systemic Vasculopathy.Biomedicines · 2026Review
- Diagnostic Value of Glycocalyx Shedding in Blood for Differentiating between Parkinson's Disease and Multiple System Atrophy.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Airway macrophage specific glycocalyx expression and remodeling following viral infection.Matrix biology : journal of the International Society for Matrix Biology · 2026Article
- Research progress of traditional Chinese medicine interventions for aging-related nervous system diseases.Biogerontology · 2026Review
- Decoding the lung-brain axis in influenza: from pulmonary infection to central nervous system injury.Journal of neuroinflammation · 2026Review
- Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers.MedComm · 2026Review
- Mechanisms and integrative machine learning approaches to blood-brain barrier biomarker profiling for personalized ischemic stroke management.Physiological reports · 2026Review
- Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood-brain barrier disruption.Cell death & disease · 2026Article
- Association of endothelial glycocalyx degradation with post-PCI slow flow phenomenon in STEMI patients: a prospective observational study.Cardiovascular diagnosis and therapy · 2026Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Sophia M ShiDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6935-1034
Ryan J SuhDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
D Judy ShonDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8379-6195
Francisco J GarciaPicower Institute for Learning and Memory, Cambridge, MA, USA.
Josephine K BuffDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0005-4189-8034
Micaiah AtkinsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0068-5217
Lulin LiPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.
Nannan LuDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0905-8199
Bryan SunPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.ORCID 0009-0002-0959-483X
Jian LuoPalo Alto Veterans Institute for Research, Palo Alto, CA, USA.ORCID 0000-0002-2064-8467
Ning-Sum ToHong Kong Center for Neurodegenerative Diseases, Hong Kong, China.
Tom H CheungHong Kong Center for Neurodegenerative Diseases, Hong Kong, China.ORCID 0000-0003-0796-5406
M Windy McNerneyDepartment of Psychiatry, Stanford University School of Medicine, Stanford, CA, USA.
Myriam HeimanPicower Institute for Learning and Memory, Cambridge, MA, USA.ORCID 0000-0002-6365-8673
Carolyn R BertozziDepartment of Chemistry, Stanford University, Stanford, CA, USA. bertozzi@stanford.edu.ORCID 0000-0003-4482-2754
Tony Wyss-CorayStanford Chemistry, Engineering and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA, USA. twc@stanford.edu.ORCID 0000-0001-5893-0831
Funding
Investigating the Surface GlycoproteomeR01CA200423 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2015 to 2026
$3.8MTargeting the Cancer GlycocalyxR01CA227942 · NCI · STANFORD UNIVERSITY · PI Carolyn Bertozzi · 2019 to 2026
$3.6MTargeting CD22 to Restore Brain Homeostasis in Alzheimer's DiseaseRF1AG064897 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2019 to 2019
$2.9MMolecular Mechanisms Underlying Cell Type-Specific Vulnerability in Huntington’s DiseaseR35NS127327 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Myriam Heiman · 2022 to 2026
$2.7MMolecular signature of parabiosisR01AG072255 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2021 to 2025
$2.4MNCI NIH HHS R01 CA200423NCI NIH HHS R01 CA227942NIA NIH HHS R01 AG072255NIA NIH HHS RF1 AG064897NINDS NIH HHS R35 NS127327
Abstract
The blood-brain barrier (BBB) is highly specialized to protect the brain from harmful circulating factors in the blood and maintain brain homeostasis
Indexed as
AgingBlood-Brain BarrierGlycocalyxNeurodegenerative DiseasesAnimalsBrainDependovirusEndothelial CellsFemaleGlycoproteinsGlycosylationHumansMaleMiceMice, Inbred C57BLMucinsGlycoproteinsMucinsPolysaccharides
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.