Evidence map›Paper›PMID 40011745›Full record

ArticleNature structural & molecular biology2025

Cryo-EM structure of the human THIK-1 K2P K

Karin E J Rödström, Bisher Eymsh, Peter Proks, Mehtab S Hayre, Sönke Cordeiro, Edward Mendez-Otalvaro, Christian Madry, Anna Rowland, Wojciech Kopec, Simon Newstead and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Gating mechanism of the two-pore-domain potassium channel THIK1.Nature structural & molecular biology · 2025
    Article
  6. Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Karin E J Rödström *Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Bisher Eymsh *Institute of Physiology, Kiel University, Kiel, Germany.
Peter Proks *Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.
Mehtab S Hayre *Kavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-4067-8233
Sönke CordeiroInstitute of Physiology, Kiel University, Kiel, Germany.
Edward Mendez-OtalvaroComputational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany.
Christian MadryInstitute of Neurophysiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Anna RowlandCerevance Ltd, Cambridge Science Park, Cambridge, UK.
Wojciech KopecComputational Biomolecular Dynamics Group, Max Planck Institute, Göttingen, Germany.ORCID http://orcid.org/0000-0001-8801-9563
Simon NewsteadKavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7432-2270
Thomas BaukrowitzInstitute of Physiology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0003-4562-0505
Marcus ScheweInstitute of Physiology, Kiel University, Kiel, Germany. m.schewe@physiologie.uni-kiel.de.ORCID http://orcid.org/0000-0002-6192-5651
Stephen J TuckerKavli Institute for Nanoscience Discovery, University of Oxford, Oxford, UK. stephen.tucker@physics.ox.ac.uk.ORCID http://orcid.org/0000-0001-8996-2000

Funding

Medical Research Council MR/W017741/1Wellcome Trust 102161Wellcome Trust 215519
6 · The paper itself

Abstract

THIK-1 (KCNK13) is a halothane-inhibited and anionic-lipid-activated two-pore domain (K2P) K

Indexed as

AnestheticsPotassium Channels, Tandem Pore DomainBinding SitesCryoelectron MicroscopyHalothaneHumansIon Channel GatingModels, MolecularProtein ConformationAnestheticsHalothanePotassium Channels, Tandem Pore Domain

Identifiers

PMID40011745
PMCPMC12263422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.