ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025
Longitudinal associations between white matter integrity, early life adversities, and treatment response following cognitive-behavioral therapy in depression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The SFB/TRR 393 Collaborative Research Centre: trajectories of affective disorders : Cognitive-emotional mechanisms of symptom change.Der Nervenarzt · 2026Review
- Complex Patterns of Altered White Matter Structural Connectivity within a 'subjective valuation network' in Treatment-Resistant Depression.bioRxiv : the preprint server for biology · 2025Article
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19 authors.
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Abstract
Cognitive-behavioral therapy (CBT) is a primary treatment for depression. Although previous research has underscored the significant roles of white matter (WM) alterations and maladaptive parenting in depression risk, their associations with CBT response remain largely unknown. This longitudinal study investigated the interplay of WM integrity changes over time, treatment response, and parenting style in patients with depression. Diffusion-tensor-imaging and clinical data were assessed in n = 65 (55% female) patients with depression before and after 20 CBT sessions and n = 65 (68% female) healthy controls (HC) in a naturalistic design. Linear-mixed-effect models compared changes in fractional anisotropy (FA) between groups and tested associations between FA changes and symptom changes. It was investigated whether parenting style predicts depressive symptoms at follow-up and whether FA changes mediate this association. Patients showed differential FA changes over time in the corpus callosum and corona radiata compared to HC (p
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