ArticleEuropean journal of clinical nutrition2025
The relation between body mass index and target organ damage and the mediating role of blood pressure.
Article in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Differential Associations of Healthy Lifestyle Latent Classes with Glycemic Transitions in Prediabetes: An Observational Study Based on CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Exploring the Linear and Non-linear Association Between BMI and Night-Time Blood Pressure Variability.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Hypertension and vascular health in the young.Current opinion in pediatrics · 2025Review
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesThe relationship between obesity and blood pressure (BP) is well known, but limited data exists regarding its relationship with target organ damage (TOD). Therefore, this study aimed to examine the relationship between body mass index (BMI) and TOD and the mediating role of BP. SUBJECTS/
methods2555 adults (52.0% women) who visited a local Hypertension Unit with valid measures on weight, height, 24 h ambulatory BP monitoring, office BP measurements, echocardiography, carotid ultrasonography and blood creatinine levels, included in this cross-sectional study. BMI was used to categorize participants as having normal weight (< 25 kg/m
resultsObesity was significantly related to 24-hour systolic BP (b = 3.72, 95%CI: 2.24-5.21, p < 0.001), CCA-IMT (b = 0.04, 95%CI: 0.02-0.05, p < 0.001), ICA-IMT (b = 0.03, 95%CI: 0.01-0.05, p = 0.020), and LVMI (b = 7.54, 95CI%: 4.25-10.83, p < 0.001). The mediation analysis revealed that 24-hour systolic BP mediated by 27.9% the relationship between BMI and CCA-IMT, by 31.3% the relationship between BMI and ICA-IMT, and by 18.1% the relationship between BMI and LVMI.
conclusionsThese results indicate that obesity is associated with indices of asymptomatic cardiac remodeling and vascular atherosclerosis, and systolic BP mediates these relationships.
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Registered trials
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