Evidence map›Paper›PMID 40011637›Full record

ArticleCommunications biology2025

The long noncoding RNA LUCAT1 regulates endometrial receptivity via the miR-495-3p/S100P axis.

Junyu Shang, Yumei Chen, Qianwen Jiang, Wenxin Li, Minjun Lu, Jiamin Zhou, Li Lin, Jie Xing, Mengxue Zhang, Shijie Zhao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junyu ShangReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yumei ChenDepartment of Central Laboratory, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Qianwen JiangCollege of Pharmacy, Guangxi University, Nanning, China.
Wenxin LiReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Minjun LuReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jiamin ZhouReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Li LinReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jie XingReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Mengxue ZhangReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Shijie ZhaoReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jingjing LuReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xuyan ShiReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yueqin LiuReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xiaolan ZhuReproductive Medicine Center, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China. zxl2517@163.com.ORCID http://orcid.org/0000-0002-0499-8045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, interest in investigating the effects of long noncoding RNAs (lncRNAs) on endometrial receptivity (ER) has increased within the field of assisted reproductive technology. Therefore, the objective of this study is to identify and analyze the role of the lncRNA LUCAT1 and to elucidate its specific mechanism in regulating ER. Hub genes associated with ER are identified via Weighted gene co-expression network analysis (WGCNA) in two datasets downloaded from the GEO database. These hub genes identified via WGCNA were subsequently validated. The combination of a dual-luciferase assay, qRT‒PCR, western blotting, and other techniques are used to investigate the molecular mechanism by which LUCAT1 regulates S100P. In this study, LUCAT1 expression is shown to significantly affect ER, and the depletion of LUCAT1 leads to impaired ER function. Additionally, LUCAT1 is shown to act as a molecular sponge for miR-495-3p, thereby modulating the expression of S100P. This modulation influences the proliferation, migration, and invasion capabilities of Ishikawa cells, as well as the adhesion of JAR cells to endometrial cells. Therefore, LUCAT1 can regulate ER via the miR-495-3p/S100P axis, which provides experimental evidence for the identification of innovative strategies aimed at enhancing endometrial receptivity.

Indexed as

Calcium-Binding ProteinsEndometriumMicroRNAsRNA, Long NoncodingCell ProliferationFemaleGene Expression RegulationHumansNeoplasm ProteinsCalcium-Binding Proteinslong non-coding RNA LUCAT1, humanMicroRNAsMIRN495 microRNA, humanNeoplasm ProteinsRNA, Long NoncodingS100P protein, human

Identifiers

PMID40011637
PMCPMC11865513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.