Trial reportScientific reports2025
Cerebellar transcranial direct current stimulation improves quality of life in individuals with chronic poststroke aphasia.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03699930 (Impact of Neuromodulation on Language Impairments in Stroke Patients), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Neuromodulation on Language Impairments in Stroke Patients: a Multimodal Double-blind Randomized Controlled Study
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Probing the linguistic cerebellum: a qualitative review of the effects of cerebellar neurostimulation on language processing.Frontiers in psychiatry · 2026Pooled it
- ORLA combined with telerehabilitation in patients with subacute Poststroke aphasia: a randomized controlled trial.Scientific reports · 2025Trial
- White matter predictors of cerebellar tDCS treatment effects in aphasia rehabilitation.Frontiers in neurologyTrial
- The Reorganization of Cerebellar Functional Network Topology in Post-stroke Aphasia: A Resting-State fMRI Study.Molecular neurobiology · 2026Article
- Role of LONP1 in human diseases: molecular mechanisms and therapeutic potential.Cellular & molecular biology letters · 2026Review
- Exploring the Effects of a Computerized Naming Intervention Combined with Cerebellar tDCS in Cantonese-Speaking Individuals with Aphasia.Brain sciences · 2026Article
- Neurostimulation with Naming Therapy for Primary Progressive Aphasia: A Pilot Study Targeting Transcranial Direct Current (tDCS) Stimulation for the Individual.Brain sciences · 2026Article
- Neuromodulation for post-stroke aphasia rehabilitation: established cortical stimulation and emerging network-based targets.Frontiers in human neuroscience · 2026Review
- Spinal cord stimulation as a novel neuromodulation strategy for enhancing language recovery in post-stroke aphasia: a hypothesis.Frontiers in human neuroscience · 2026Article
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Efficacy of Transcranial Magnetic Stimulation and Transcranial Direct-Current Stimulation in Primary Progressive Aphasia Treatment: A Review.Brain sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cerebellum has emerged as a potential target for transcranial direct current stimulation (tDCS) in post-stroke aphasia (PSA) due to its role in language processing and relative preservation compared to supratentorial lesions. Recent evidence also highlights the cerebellum's involvement in affective and social processes, suggesting potential broader effects of cerebellar modulation. This study investigated the efficacy of anodal tDCS over the right cerebellum paired with speech and language therapy in enhancing language functions and quality of life in individuals with PSA. Twenty-two participants with chronic PSA received cerebellar tDCS, while historical sham control data from 25 participants were obtained. Language outcomes were assessed using the Western Aphasia Battery-Revised (WAB-R), and secondary outcomes included patient-reported measures of communication effectiveness and quality of life. Mixed-design analyses of variance were conducted to examine treatment effects. No significant Group x Time interaction was found for WAB-R scores, indicating that tDCS did not provide additional language benefits over speech therapy. However, a significant Group x Time interaction was observed for the Stroke and Aphasia Quality of Life Scale-39 scores, driven by improvements in the Psychosocial, Physical, and Energy subdomains in the tDCS group. Cerebellar tDCS did not significantly improve language outcomes in PSA individuals but enhanced specific aspects of quality of life. These findings highlight the cerebellum's multifaceted role in cognitive, affective, and sensorimotor processes. Future research should focus on conducting well-powered, randomized, double-blind, and concurrent trials to validate these findings and explore optimal stimulation parameters in PSA rehabilitation.Trial registration: The trial is registered at ClinicalTrials.gov with the registration number NCT03699930. The date of registration is 10/05/2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.