Evidence map›Paper›PMID 40011571›Full record

ArticleScientific reports2025

Unveiling the antiviral inhibitory activity of ebselen and ebsulfur derivatives on SARS-CoV-2 using machine learning-based QSAR, LB-PaCS-MD, and experimental assay.

Silpsiri Sinsulpsiri, Yuji Nishii, Qing-Feng Xu-Xu, Masahiro Miura, Patcharin Wilasluck, Kanokwan Salamteh, Peerapon Deetanya, Kittikhun Wangkanont, Aphinya Suroengrit, Siwaporn Boonyasuppayakorn and 7 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Silpsiri SinsulpsiriCenter of Excellence in Biocatalyst and Sustainable Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Yuji NishiiInnovative Catalysis Science Division, Institute for Open and Transitionary Research Initiatives (ICS-OTRI), Osaka University, Suita, 565-0871, Japan.
Qing-Feng Xu-XuInnovative Catalysis Science Division, Institute for Open and Transitionary Research Initiatives (ICS-OTRI), Osaka University, Suita, 565-0871, Japan.
Masahiro MiuraInnovative Catalysis Science Division, Institute for Open and Transitionary Research Initiatives (ICS-OTRI), Osaka University, Suita, 565-0871, Japan.
Patcharin WilasluckCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Kanokwan SalamtehCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Peerapon DeetanyaCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Kittikhun WangkanontCenter of Excellence for Molecular Biology and Genomics of Shrimp, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Aphinya SuroengritCenter of Excellence in Vaccine Research and Development, Chulalongkorn University (Chula-VRC), Bangkok, 10330, Thailand.
Siwaporn BoonyasuppayakornCenter of Excellence in Vaccine Research and Development, Chulalongkorn University (Chula-VRC), Bangkok, 10330, Thailand.
Lian DuanGraduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Ibaraki, 305-8571, Japan.
Ryuhei HaradaCenter for Computational Sciences (CCS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Kowit HengphasatpornCenter for Computational Sciences (CCS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Yasuteru ShigetaCenter for Computational Sciences (CCS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.
Liyi ShiResearch Center of Nano Science and Technology, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, People's Republic of China.
Phornphimon MaitaradResearch Center of Nano Science and Technology, Department of Chemistry, College of Science, Shanghai University, Shanghai, 200444, People's Republic of China. pmaitarad@shu.edu.cn.
Thanyada RungrotmongkolCenter of Excellence in Biocatalyst and Sustainable Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand. t.rungrotmongkol@gmail.com.

Funding

Biometal Sciences, Japan 22H04800Japan Science and Technology Agency JPMJCR20B3National Research Council of Thailand N42A650231Shanghai International Funding G2023013060L
6 · The paper itself

Abstract

Ebsulfur and ebselen derivatives that were proven to be potent inhibitors against the main protease (M

Indexed as

Antiviral AgentsAzolesOrganoselenium CompoundsSARS-CoV-2Coronavirus 3C ProteasesCOVID-19COVID-19 Drug TreatmentHumansIsoindolesMachine LearningMolecular Docking SimulationMolecular Dynamics SimulationNeural Networks, ComputerQuantitative Structure-Activity RelationshipAntiviral AgentsAzolesCoronavirus 3C ProteasesebselenIsoindolesOrganoselenium CompoundsEbselen and ebsulfur derivativesLB-PaCS-MDMachine learningQSARSARS-CoV-2 inhibitory activity

Identifiers

PMID40011571
PMCPMC11865625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.