Evidence map›Paper›PMID 40011461›Full record

ArticleNPJ biofilms and microbiomes2025

Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device.

João Gabriel S Souza, Fabio Azevedo, Maria Helena Rossy Borges, Raphael Cavalcante Costa, Takahiko Shiba, Shlomo Barak, Yaniv Mayer, Luciene Cristina de Figueiredo, Magda Feres, Valentim A R Barão and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07045636 (Microbial Modulation by PEMF on Paque Induced Mucositis in Dental Implants Placed in Human Jaws), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07045636 nacompletednot on this map

Microbial Modulation by PEMF on Paque Induced Mucositis in Dental Implants Placed in Human Jaws: Microbiome and Proteomic Analysis.

TypeinterventionalSponsorJamil awad shibliRan2025 to 2025Enrolled35ConditionsMicrobial Colonization, Peri-ImplantitisArmsPEMF abd Sham (control), Teeth wih gingivits
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

João Gabriel S SouzaDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil. jgabriel.ssouza@yahoo.com.br.
Fabio AzevedoDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.
Maria Helena Rossy BorgesDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, Brazil.
Raphael Cavalcante CostaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, Brazil.
Takahiko ShibaDepartment of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, 02115, USA.
Shlomo BarakDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.
Yaniv MayerDepartment of Periodontology, Rambam Health Care Campus, Haifa, Israel.
Luciene Cristina de FigueiredoDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.
Magda FeresDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.
Valentim A R BarãoDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, Brazil.
Jamil A ShibliDepartment of Periodontology, Dental Research Division, Guarulhos University, Guarulhos, São Paulo, 07023-070, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored. Thus, we tested a miniaturized PEMF biomedical device as a healing component for dental implants. PEMF activation did not alter the chemical composition, surface roughness, wettability, and electrochemical performance. PEMF effectively controlled chronic in vitro polymicrobial microbial accumulation. The in vivo study where devices were inserted in the patients' oral cavities and 16S RNA sequencing analysis evidenced a fivefold or more reduction in 23 bacterial species for PEMF group and the absence of some species for this group, including pathogens associated with implant-related infections. PEMF altered bacterial interactions and promoted specific bacterial pathways. PEMF has emerged as an effective strategy for controlling implant-related infections.

Indexed as

BacteriaDental ImplantsElectromagnetic FieldsMicrobiotaProsthesis-Related InfectionsBiofilmsFemaleHumansMaleRNA, Ribosomal, 16SDental ImplantsRNA, Ribosomal, 16S

Identifiers

PMID40011461
PMCPMC11865433

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.