Evidence map›Paper›PMID 40011393›Full record

ArticleThe AAPS journal2025

Unraveling Ceftriaxone Dosing: Free Drug Prediction, Threshold Optimization, and Model Validation.

Johnny Michel, Francesco Monti, Fabien Lamoureux, Djibril Diagouraga, Manuel Etienne, Muriel Quillard, Camille Molkhou, Fabienne Tamion, Sandrine Dahyot, Tania Petersen and 4 more

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in The AAPS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Johnny MichelEmergency Department, CHU Rouen, F-76000, Rouen, France.
Francesco MontiDepartment of Digital Health, CHU Rouen, F-76000, Rouen, France.
Fabien LamoureuxDepartment of Pharmacology, CHU Rouen, F-76000, Rouen, France.
Djibril DiagouragaDepartment of Pharmacology, CHU Rouen, F-76000, Rouen, France.
Manuel EtienneDepartment of Infectious Diseases, Univ Rouen Normandie, Univ Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, CHU Rouen, F-76000, Rouen, France.
Muriel QuillardDepartment of Biochemistry, CHU Rouen, F-76000, Rouen, France.
Camille MolkhouDepartment of Medical Intensive Care Unit, CHU Rouen, F-76000, Rouen, France.
Fabienne TamionDepartment of Medical Intensive Care Unit, CHU Rouen, F-76000, Rouen, France.
Sandrine DahyotDepartment of Bacteriology, Univ Rouen Normandie, Univ Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, CHU Rouen, F-76000, Rouen, France.
Tania PetersenDepartment of Pharmacology, CHU Rouen, F-76000, Rouen, France.
Tony PereiraDepartment of Pharmacology, CHU Rouen, F-76000, Rouen, France.
Martine Pestel-CaronDepartment of Bacteriology, Univ Rouen Normandie, Univ Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, CHU Rouen, F-76000, Rouen, France.
Julien GrosjeanDepartment of Digital Health, CHU Rouen, F-76000, Rouen, France.
Thomas DuflotDepartment of Pharmacology, Univ Rouen Normandie, INSERM, Normandie Univ, EnVI UMR1096, CHU Rouen, F-76000, Rouen, France. thomas.duflot@chu-rouen.fr.ORCID 0000-0002-8730-284X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ceftriaxone is pivotal in treating severe infections; however, predicting unbound plasma ceftriaxone (CEF

Indexed as

Anti-Bacterial AgentsCeftriaxoneModels, BiologicalAdultAgedFemaleHumansMaleMicrobial Sensitivity TestsMiddle AgedRetrospective StudiesAnti-Bacterial AgentsCeftriaxoneceftriaxonecomputational biologyfree fractionmodelingpharmacodynamics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.