ArticleClinical and experimental nephrology2025
Exploring the causal association between circulating leukocyte count and IgA nephropathy based on two-sample Mendelian randomization: possible role of transitional B cells.
Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo examine the causal association between genetically predicted circulating leukocyte counts and IgA nephropathy.
methodsA two-sample Mendelian randomization (MR) design was used. The exposures were the neutrophil, lymphocyte (with subsequent analyses for memory B-cell %lymphocyte, IgD
resultsThe genetic prediction results showed causal associations between the neutrophil counts and IgA nephropathy (OR = 2.62, 95%CI 2.47-2.77, P < 0.001) and between the lymphocyte counts and IgA nephropathy (OR = 0.76, 95%CI 0.58-0.99, P = 0.04). Monocyte, basophil, and eosinophil counts showed no causal associations with IgA nephropathy. The supplementary genetic prediction analyses showed a causal association between transitional %lymphocytes and IgA nephropathy (OR = 0.58, 95%CI 0.39-0.87, P = 0.008). Cochran's Q test revealed heterogeneity for the neutrophil, lymphocyte, monocyte, eosinophil, transitional %lymphocytes, and count analyses (all P < 0.05), but the MR-Egger test revealed no pleiotropy. After removing the outliers, the associations remained the same.
conclusionCausal associations were observed between neutrophil and lymphocyte counts as exposures and IgA nephropathy as outcome. Among lymphocytes, transitional B cells could be involved in the pathogenesis of IgA nephropathy. Attention should be paid to neutrophil and lymphocyte counts in future studies on IgA nephropathy.
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