Evidence map›Paper›PMID 40011349›Full record

ArticleGeroScience2025

Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice.

Marisa Ferreira-Marques, Sara Carmo-Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López-Otín, Luís Pereira de Almeida, Célia A Aveleira, Cláudia Cavadas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marisa Ferreira-Marques *CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Sara Carmo-Silva *H&TRC - Health and Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, Coimbra, Portugal.
Joana PereiraCNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Mariana BotelhoCNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Clévio NóbregaAlgarve Biomedical Center Research Institute (ABC-RI), University of Algarve, Faro, Portugal.
Carlos López-OtínDepartamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.
Luís Pereira de AlmeidaCNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Célia A Aveleira *CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Cláudia Cavadas *CNC-UC, Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. ccavadas@uc.pt.ORCID 0000-0001-8020-9266

Funding

European Regional Development Fund CENTRO-01-0145-FEDER-000012European Regional Development Fund CENTRO-01-0246-FEDER-000010 (MIA-Portugal)Fundação para a Ciência e a Tecnologia COVID/BD/152130/2021Fundação para a Ciência e a Tecnologia IF/00825/2015Fundação para a Ciência e a Tecnologia LA/P/0058/2020Fundação para a Ciência e a Tecnologia POCI-01-0145-FEDER-030167Fundação para a Ciência e a Tecnologia SFRH/BD/120023/2016Fundação para a Ciência e a Tecnologia UIDB/04539/2020H2020 Spreading Excellence and Widening Participation 857524HORIZON EUROPE European Research Council 742067Progeria Research Foundation (PRF2014-53Progeria Research Foundation PRF2015-60
6 · The paper itself

Abstract

The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during aging, we investigated if reestablishment of NPY levels mitigate aging phenotype, using a mouse model of premature aging - Zmpste24

Indexed as

Aging, PrematureHypothalamusNeuropeptide YAgingAnimalsAutophagyCaloric RestrictionDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeNeuropeptide YBiology of agingBrain agingHypothalamusNeuropeptide Y

Identifiers

PMID40011349
PMCPMC12397475

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.