Evidence map›Paper›PMID 40011329›Full record

ArticleNeurocritical care2025

Prognostic Significance of Preoperative Perihematomal Edema in Spontaneous Cerebellar Hemorrhage After Minimally Invasive Surgery.

Haixiao Liu, Dongbo Li, Yaning Cai, Longlong Zheng, Zhijun Tan, Feng Liu, Fei Gao, Hui Zhang, Yong Du, Gaoyang Zhou and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurocritical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

21 authors.

Haixiao Liu *Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Dongbo Li *Shaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Yaning CaiDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Longlong ZhengDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Zhijun TanDepartment of Health Statistics, The Fourth Military Medical University, Xi'an, China.
Feng LiuShaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Fei GaoShaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Hui ZhangShaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Yong DuDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Gaoyang ZhouDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Feifei SunDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Ruixi FanDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Ping WangDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Lei WangDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Shunnan GeDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Tianzhi ZhaoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Tao ZhangDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Rongjun ZhangShaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Guoqiang XieShaanxi Clinical Research Center for Neurosurgical Diseases, Xi'an, China.
Yan QuDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Wei GuoDepartment of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. 18729985168@163.com.ORCID 0000-0001-9753-9165

Funding

National Natural Science Foundation of China 82101379National Natural Science Foundation of China 82130038National Natural Science Foundation of China 82371384
6 · The paper itself

Abstract

backgroundMinimally invasive surgery (MIS), including endoscopic evacuation and minimally invasive catheter (MIC) evacuation, has been widely used in patients with spontaneous cerebellar hemorrhage (SCH). However, the long-term prognosis varies widely. Herein, a case-control study nested within a multicenter cohort was conducted to explore the risk factors for unfavorable prognosis in patients with SCH after MIS.

methodsThe data on medical history, perioperative computed tomography scans, and 6-month prognosis of the observed patients were collected. A comparison of these variables between patients with favorable outcomes (modified Rankin Scale score ≤ 3) and those with unfavorable outcomes (modified Rankin Scale score ≥ 4) was conducted to investigate prognostic predictors.

resultsEighty patients from four clinical centers were enrolled in the present study. Four factors including advanced age, MIC evacuation, large postoperative perihematomal edema (PHE), and large preoperative PHE were identified as independent risk factors for 6 month unfavorable neurological outcome. Subsequent analysis demonstrated that preoperative PHE serves as a reliable predictor of unfavorable neurological outcome at 6 months (area under the curve = 0.849). Based on restricted cubic spline analysis, patients were subsequently stratified into a large preoperative PHE (≥ 10 ml) subgroup and a small preoperative PHE (< 10 ml) subgroup. The incidence of unfavorable outcomes in the large preoperative PHE subgroup (47.4%) was significantly higher than that in the small preoperative PHE subgroup (2.4%).

conclusionsAdvanced age, MIC evacuation, large preoperative PHE, and postoperative PHE are independent factors associated with unfavorable outcome in patients with SCH who underwent MIS. Significantly, the large preoperative PHE is an independent predictor for unfavorable long-term neurological outcome, particularly when the preoperative PHE is ≥ 10 ml.

Indexed as

Brain EdemaCerebellar DiseasesCerebral HemorrhageHematomaMinimally Invasive Surgical ProceduresOutcome Assessment, Health CarePostoperative ComplicationsAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedPrognosisRisk FactorsNeurological outcomePerihematomal edemaResidual hematomaSpontaneous cerebellar hemorrhage

Identifiers

PMID40011329

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