Evidence map›Paper›PMID 40011244›Full record

ArticleMikrochimica acta2025

A novel photoelectrochemical strategy for ultrasensitive and simultaneous detection of 5-methylcytosine and N6-methyladenosine based on proximity binding-triggered assembly MNAzyme -mediated HRCA.

Yue Hu, Mengshi Xia, Mimi Li, Lulu Li, Chenghong Li, Yi Liu, Lina Wang, Hui Huang, Lichao Fang, Kexing Peng and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yue Hu *Emergency Department, 2, Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Mengshi Xia *Emergency Department, 2, Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Mimi LiEmergency Department, 2, Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Lulu LiDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Chenghong LiDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Yi LiuDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Lina WangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Hui HuangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Lichao FangDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.
Kexing PengEmergency Department, 2, Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Huamin LiuDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. liuhuamindd@sina.com.
Xiaolong WangEmergency Department, 2, Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. wang.xiaolong@cqmu.edu.cn.
Junsong ZhengDepartment of Clinical and Military Laboratory Medicine, College of Pharmacy and Laboratory Medicine, Army Medical University), Third Military Medical University, No. 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. zhengalpha@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The preparation of UiO-66@CdTe@AuNPs composites is presented for the first time, which function as a photoelectrochemical (PEC) sensing matrix and are conjugated to a three-way junction (TWJ). We propose an antibody-based specific recognition-induced neighbor-joining reaction that initiates the assembly of two molecularly designed nucleic acid enzymes (MNAzymes), to release an oligonucleotide that hydrolyzes TWJ through the mechanism of a toehold-mediated strand displacement reaction (TSDR). Subsequently, a hybridization chain reaction application (HRCA)-based dendrimer is formed, which immobilizes a large number of quantum dots to generate a burst effect that reduces the photocurrent signal. As anticipated, the developed PEC biosensor showed excellent analytical performance for both m

Indexed as

5-MethylcytosineAdenosineBiosensing TechniquesDNA, CatalyticElectrochemical TechniquesCadmium CompoundsGoldHumansLimit of DetectionMetal NanoparticlesNucleic Acid HybridizationPhotochemical ProcessesQuantum DotsTellurium5-MethylcytosineAdenosineCadmium Compoundscadmium tellurideDNA, CatalyticGoldN-methyladenosineTelluriumBioassayHybridization chain reaction applicationPhotoelectrochemical strategyRNA methylation

Identifiers

PMID40011244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.