Evidence map›Paper›PMID 40011089›Full record

ArticleTrends in cell biology2025

Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes.

Woo Yong Park, Claudia Montufar, Elma Zaganjor

Abstract read
In one paragraph

Article in Trends in cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Woo Yong ParkDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Claudia MontufarDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Elma ZaganjorDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA; Center for Stem Cell Biology, Vanderbilt University, Nashville, TN, USA. Electronic address: elma.zaganjor@vanderbilt.edu.

Funding

Reprogramming cell fate through nucleotide metabolismR35GM154684 · NIGMS · VANDERBILT UNIVERSITY · PI Elma Zaganjor · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM154684
6 · The paper itself

Abstract

Mitochondrial metabolism, signaling, and dynamics are key regulators of cell fate. While glycolysis supports stemness, mitochondrial expansion and oxidative phosphorylation (OXPHOS) facilitate differentiation. This forum presents emerging evidence that the type of substrate, whether amino acids, carbohydrates, or fatty acids, oxidized by mitochondria significantly influences differentiation outcomes.

Indexed as

Cell DifferentiationMitochondriaAnimalsGlycolysisHumansOxidation-ReductionOxidative Phosphorylationamino acidsdifferentiationfatty acidsglucosemitochondriaOXPHOS

Identifiers

PMID40011089
PMCPMC11972143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.