Evidence map›Paper›PMID 40010998›Full record

ArticleIn vivo (Athens, Greece)

Effect of Hypoxia on Irisin Secretion by Human Cardiomyocytes.

Maciej Grzeszczuk, Urszula Ciesielska, Agnieszka Rusak, Michał Jerzy Kulus, Katarzyna Haczkiewicz-Leśniak, Karolina Jabłońska, Alicja Kmiecik, Marzenna Podhorska-Okołów, Piotr Dzięgiel, Katarzyna Nowińska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maciej GrzeszczukDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland; maciej.grzeszczuk@student.umw.edu.pl.
Urszula CiesielskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Agnieszka RusakDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Michał Jerzy KulusDivision of Ultrastructural Research, Wroclaw Medical University, Wroclaw, Poland.
Katarzyna Haczkiewicz-LeśniakDivision of Ultrastructural Research, Wroclaw Medical University, Wroclaw, Poland.
Karolina JabłońskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Alicja KmiecikDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Marzenna Podhorska-OkołówDivision of Ultrastructural Research, Wroclaw Medical University, Wroclaw, Poland.
Piotr DzięgielDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
Katarzyna NowińskaDivision of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimCardiovascular disease (CVD) is the leading cause of death worldwide, accounting for 31% of all deaths. Biomarkers such as troponins and natriuretic peptides are crucial in diagnosing CVD. Recently, irisin (Ir), a myokine derived from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5), has been identified as a potential new biomarker for CVD. Ir is involved in regulating energy metabolism. This study aimed to determine the expression levels of the MATERIALS AND

methodsAC16 cardiomyocytes were cultured under hypoxic conditions for two, four, and six hours. Molecular studies were conducted using western blot, immunofluorescence, RT-PCR, immunoenzymatic test (ELISA), and electron microscopy methods.

results

conclusionIr could be a potentially useful indicator for assessing CVD risk. Further research is needed to confirm whether elevated Ir levels under hypoxic conditions in AC16 cells represent a promising direction for the development of biomarkers for CVD.

Indexed as

FibronectinsHypoxiaMyocytes, CardiacBiomarkersCell HypoxiaCell LineGene Expression RegulationHumansBiomarkersFibronectinsFNDC5 protein, humanCardiovascular diseasesFNDC5HIF1αhypoxiaIrisinPGC1α

Identifiers

PMID40010998
PMCPMC11884492

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.