Evidence map›Paper›PMID 40010974›Full record

ArticleIn vivo (Athens, Greece)

An Unexpected Relationship Between Human Papillomavirus and Head and Neck Squamous Cell Carcinoma: A Mendelian Randomization Study.

Yong Feng, Juan Zhai, Tobias Vollkommer, Martin Gosau, Ralf Smeets, Rico Rutkowski, Jieheng Wu, Liyuan Xiao, Reinhard E Friedrich

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yong Feng *Department of Implantology, Guiyang Hospital of Stomatology, Guiyang, P.R. China.
Juan Zhai *Department of Implantology, Guiyang Hospital of Stomatology, Guiyang, P.R. China.
Tobias VollkommerDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martin GosauDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ralf SmeetsDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rico RutkowskiDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jieheng WuDepartment of Immunology, Guizhou Medical University, Guiyang, P.R. China; immunewjh@163.com.
Liyuan XiaoDepartment of Implantology, Guiyang Hospital of Stomatology, Guiyang, P.R. China; cnliyuan.xiao@hotmail.com.
Reinhard E FriedrichDepartment of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHead and neck cancer (HNC) is the sixth most common type of cancer worldwide. While it is widely accepted that human papillomavirus (HPV) infection is a crucial risk factor for the development of this type of cancer, there is still a lack of support from large-scale studies. This article addresses this gap by comprehensively analyzing the causal relationship between HPV infection and head and neck cancer using Mendelian randomization methods. PATIENTS AND

methodsThe HPV database was utilized to identify instrumental variables

resultsThe results indicated no causal relationship between HPV16/18 E7 proteins and head and neck cancer, oral cancer, oropharyngeal cancer, and laryngeal cancer, including UKB database and GEME-ON network. Furthermore, there was no heterogeneity or horizontal pleiotropy in the data.

conclusionThe analysis does not support a causal relationship between HPV infection and HNC, as indicated by the lack of evidence linking HPV16/18 E7 proteins to the development of this cancer.

Indexed as

Head and Neck NeoplasmsMendelian Randomization AnalysisPapillomaviridaePapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckGenetic Predisposition to DiseaseGenome-Wide Association StudyHuman Papillomavirus VirusesHumansPolymorphism, Single NucleotideRisk Factorscausal effectHead and neck cancerhuman papillomavirusesMendelian randomization

Identifiers

PMID40010974
PMCPMC11884452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.