Evidence map›Paper›PMID 40010946›Full record

ArticleIn vivo (Athens, Greece)

A New Approach to Highly Conformal Hippocampal-sparing Whole-brain Radiotherapy: A Feasibility Study.

Christian Ziemann, Florian Cremers, Miller MacPherson, Dirk Rades, Anastassia Löser

Abstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christian ZiemannDepartment of Radiation Oncology, University of Lübeck, Lübeck, Germany; christian.ziemann@uksh.de.
Florian CremersDepartment of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Miller MacPhersonDivision of Medical Physics, Department of Radiology, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Dirk RadesDepartment of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Anastassia LöserDepartment of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimHippocampal-sparing whole-brain radiotherapy (HS-WBRT) is increasingly used for multiple brain metastases. However, most studies have not reported dose conformity indices ( PATIENTS AND

methodsTen patients received 30 Gy of HS-WBRT for brain metastases. Three variants of treatment plans (VAR1, VAR2, VAR3) were investigated. Volumetric modulated arc therapy plans with two (2ROT) or three rotations (3ROT) were created for each variant. Plans were compared for compliance with hippocampal sparing criteria,

resultsBest results (highest

conclusionOur new technique achieved both appropriate hippocampal sparing and very high dose conformity of ≥0.9. Significant underdosage outside the hippocampal-sparing area was avoided.

Indexed as

Brain NeoplasmsCranial IrradiationHippocampusOrgan Sparing TreatmentsRadiotherapy, ConformalFeasibility StudiesFemaleHumansMaleMiddle AgedOrgans at RiskRadiotherapy DosageRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-Assistedbrain metastasesdose conformityHippocampal sparingneurocognitionwhole-brain radiotherapy

Identifiers

PMID40010946
PMCPMC11884443

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.