Evidence map›Paper›PMID 40010848›Full record

ArticleJournal of neurointerventional surgery2026

Catheterization complications of intra-arterial chemotherapy for retinoblastoma.

Craig Schreiber, Gary Kocharian, Natasha Kharas, Jared Knopman, Jasmine H Francis, David H Abramson, Y Pierre Gobin

Abstract read
In one paragraph

Article in Journal of neurointerventional surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Craig SchreiberDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA cpq9005@med.cornell.edu.ORCID http://orcid.org/0000-0002-5027-5403
Gary KocharianDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.ORCID http://orcid.org/0000-0002-8261-0536
Natasha KharasDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
Jared KnopmanDepartment of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA.
Jasmine H FrancisDepartment of Surgery, Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
David H AbramsonDepartment of Surgery, Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Y Pierre GobinDivision of Interventional Neuroradiology, New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundIntra-arterial chemotherapy (IAC) is a growing method of therapy for retinoblastoma (Rb). There is an absence of data to support the safety of catheterization with intra-arterial infusion in this pediatric population

objectiveTo focus on the non-ocular catheter/procedural-related complications that our practice has experienced in order to lay a foundation for practices interested in performing these procedures and hopefully, to help prevent them from occurring.

methodsThis is a retrospective review of the patient population with Rb treated in our center from May 2006 through May 2024. Every procedure performed was reviewed for non-ocular catheterization-related complications. This review included complications of access, the distal vessel (thrombosis, stenosis, and dissection), and non-ocular infarcts.

resultsThere were 2281 vascular access events, and 2681 distal catheterization procedures were performed for IAC infusion on 623 pediatric patients with Rb. Mean age of the population was 18.9 months. There were 31 complications directly related to catheterization: 7 (0.3%) related to femoral artery access and 24 (0.9%) were distal vessel injuries. Two (0.07% of total catheterizations) of the distal vessel injuries were asymptomatic cerebral infarcts diagnosed on follow-up MRI.

conclusionCatheterization with IAC can be performed safely in this young pediatric population. There is a trend for fewer complications when using the smallest catheter system possible for procedures.

Indexed as

Antineoplastic AgentsInfusions, Intra-ArterialRetinal NeoplasmsRetinoblastomaChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesAntineoplastic AgentsAngiographyCatheterComplicationPediatricsTechnique

Identifiers

PMID40010848
PMCPMC12747138

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