Evidence map›Paper›PMID 40010447›Full record

ArticleAnnals of epidemiology2025

Time-space characteristics of emergency medical service attendance and layperson naloxone administration during non-fatal opioid overdoses in Rhode Island: A retrospective, event-level analysis.

Joseph G Rosen, Melissa Basta, Kristen St John, Benjamin D Hallowell, Maxwell S Krieger, Lila Flavin, Ju Nyeong Park

Abstract read
In one paragraph

Article in Annals of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Locations of emergency medical services attended non-fatal opioid-involved overdoses, 888 counties, USA, 2022-2024.Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph G RosenDepartment of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA; Division of General Internal Medicine, Rhode Island Hospital, Providence, RI, USA. Electronic address: joseph_g_rosen@brown.edu.
Melissa BastaSubstance Use Epidemiology Program, Rhode Island Department of Health, Providence, RI, USA.
Kristen St JohnSubstance Use Epidemiology Program, Rhode Island Department of Health, Providence, RI, USA.
Benjamin D HallowellSubstance Use Epidemiology Program, Rhode Island Department of Health, Providence, RI, USA.
Maxwell S KriegerDepartment of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.
Lila FlavinDepartment of Addiction Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA.
Ju Nyeong ParkDepartment of Medicine, Warren Alpert Medical School, Brown University, Providence, RI, USA; Division of General Internal Medicine, Rhode Island Hospital, Providence, RI, USA; Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI CURT G BECKWITH · 2018 to 2026
$23.4M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIGMS NIH HHS P20 GM125507NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

purposeAs the opioid overdose crisis worsens in the United States (U.S.), emerging scholarship has uncovered time-and-place variations in substance use and overdose response efforts in community settings. Building on this work, we characterized spatio-temporal attributes of naloxone administration during non-fatal opioid overdoses attended by laypersons and emergency medical services (EMS) over a three-year period.

methodsLeveraging EMS encounter data across Rhode Island between January 2020 and December 2022, we quantified hour-by-hour variations in EMS deployment locations for non-fatal opioid-involved overdoses among adults (aged 18 + years). We used multivariable Poisson regression with robust standard errors to identify spatio-temporal patterns in EMS-attended overdoses by location type and evidence of layperson naloxone administration during these events.

resultsOf the 5377 EMS non-fatal opioid overdose encounters, most occurred in residential housing (61.1 %) and outdoor public spaces (19.3 %). We identified substantial time-space variations in non-fatal overdoses, with EMS deployments to residential housing clustering in non-daylight hours (5:00PM-8:59AM) and to outdoor public spaces in daylight hours (9:00AM-8:59PM). Documented naloxone intervention by laypersons prior to EMS arrival was uncommon (10.6 %) but was most pronounced in overdoses occurring in residential housing and the early afternoon (1:00PM-4:59PM).

conclusionsDespite the clustering of non-fatal opioid overdoses in housing environments, we identified substantial within-location variations in overdose-related EMS encounters over time and place.

Indexed as

Analgesics, OpioidDrug OverdoseEmergency Medical ServicesNaloxoneNarcotic AntagonistsOpiate OverdoseAdolescentAdultFemaleHumansMaleMiddle AgedOpioid-Related DisordersRetrospective StudiesRhode IslandSpatio-Temporal AnalysisAnalgesics, OpioidNaloxoneNarcotic AntagonistsEMSNon-fatal drug overdoseOpioidsOverdose reversalPeople who use drugsUnited States

Identifiers

PMID40010447
PMCPMC12199661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.