Evidence map›Paper›PMID 40010015›Full record

ArticleNeurobiology of aging2025

Advancing age and sex modulate antidyskinetic efficacy of striatal Ca

Margaret E Caulfield, Molly J Vander Werp, Jennifer A Stancati, Timothy J Collier, Caryl E Sortwell, Ivette M Sandoval, Jeffrey H Kordower, Fredric P Manfredsson, Kathy Steece-Collier

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Gene therapy downregulating CaV1.3 reverses motor disability in aged parkinsonian male and female macaques.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret E CaulfieldDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA.
Molly J Vander WerpDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA.
Jennifer A StancatiDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA.
Timothy J CollierDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA.
Caryl E SortwellDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA.
Ivette M SandovalParkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Jeffrey H KordowerASU-Banner Neurodegenerative Disease Research Center (NDRC), College of Liberal Arts and Sciences, Arizona State University, Tempe, AZ 85287, USA.
Fredric P ManfredssonParkinson's Disease Research Unit, Department of Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ 85013, USA.
Kathy Steece-CollierDepartment of Translational Neuroscience, College of Human Medicine, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI 49503, USA. Electronic address: collie68@msu.edu.

Funding

Genetic Silencing of Striatal CaV1.3 Calcium Channels as a Potent Antidyskinetic Therapy for PDR01NS110398 · NINDS · MICHIGAN STATE UNIVERSITY · PI Jeffrey H Kordower, Fredric Manfredsson · 2018 to 2026
$5.3M
Striatal CaV1.3 Calcium Channels: An Overlooked Antidyskinetic Target for PDR21NS090107 · NINDS · MICHIGAN STATE UNIVERSITY · PI STEECE-COLLIER, KATHY · 2015 to 2016
$384k
NINDS NIH HHS R01 NS110398NINDS NIH HHS R21 NS090107
6 · The paper itself

Abstract

We previously demonstrated that viral vector-mediated striatal Ca

Indexed as

AgingCalcium Channels, L-TypeCorpus StriatumDyskinesia, Drug-InducedGenetic TherapyParkinson DiseaseSex CharacteristicsAnimalsCalcium ChannelsDisease Models, AnimalFemaleGenetic VectorsLevodopaMaleRatsRNA, Small InterferingCacna1d protein, ratCalcium ChannelsCalcium Channels, L-TypeLevodopaRNA, Small InterferingAgingCaV1.3 calcium channelsGene therapyLevodopa-induced dyskinesiaParkinson's disease

Identifiers

PMID40010015
PMCPMC12007665

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.