Evidence map›Paper›PMID 40009898›Full record

Observational studyThe Journal of surgical research2025

Racial Variability in Platelet Response Among Patients With Peripheral Artery Disease.

Sasha P Suarez Ferreira, Adriana A Rodriguez Alvarez, Isabella Ferlini Cieri, Shiv Patel, Mounika Boya, Kellie Machlus, Trisha Roy, Anahita Dua

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of surgical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sasha P Suarez FerreiraDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Department of Surgery, Northwestern Medicine, Chicago, Illinois.
Adriana A Rodriguez AlvarezDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Isabella Ferlini CieriDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Shiv PatelDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Mounika BoyaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Kellie MachlusVascular Biology Program, Boston Children's Hospital and Department of Surgery, Harvard Medical School, Boston, Massachusetts.
Trisha RoyDepartment of Cardiovascular Surgery, Houston Methodist, Weill Cornell Medical College, Houston, Texas.
Anahita DuaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: adua1@mgh.harvard.edu.

Funding

Preventing Graft Thrombosis in the Elderly through Development of a Risk Prediction ToolR21AG077310 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI DUA, ANAHITA · 2022 to 2023
$476k
NIA NIH HHS R21 AG077310
6 · The paper itself

Abstract

introductionPeripheral artery disease (PAD) is prevalent among the elderly population, with Black Americans facing a higher incidence and complications than White Americans. Antiplatelet therapy is crucial for PAD. This observational study aims to discern racial variability in platelet function using viscoelastic assays in patients' postrevascularization for PAD.

methodsPatients with PAD who underwent revascularization between December 2020 and October 2023 were prospectively enrolled. The cohort was divided by race and antiplatelet therapy regimen. Serial perioperative Thromboelastography with Platelet Mapping assays were performed, and the platelet function was evaluated.

resultsA total of 42 patients met the study criteria, and 99 samples were analyzed. In the Thromboelastography with Platelet Mapping assay, the White-Americans cohort showed a significantly lower maximum amplitude (clot strength), lower percentage of platelet aggregation (platelet reactivity), and a significantly higher percentage of platelet inhibition than Black, Asian, and Hispanic Americans on the same antiplatelet regimen.

conclusionsThese findings suggest potential racial disparities in platelet response to standard medications, highlighting the critical need for personalized pharmacological approaches that account for genetic and physiological variations across different ethnic populations. Further research is essential to elucidate the underlying mechanisms of these differential platelet responses, which could have significant implications for precision medicine and targeted therapeutic strategies.

Indexed as

Blood PlateletsPeripheral Arterial DiseasePlatelet Aggregation InhibitorsAgedAged, 80 and overBlack or African AmericanFemaleHispanic or LatinoHumansMaleMiddle AgedPlatelet AggregationPlatelet Function TestsProspective StudiesThrombelastographyWhitePlatelet Aggregation InhibitorsAntiplateletPeripheral artery diseasePlatelet mappingRaceRevascularizationThromboelastographyThrombosis

Identifiers

PMID40009898
PMCPMC11972142

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.