Evidence map›Paper›PMID 40009671›Full record

ArticleScience advances2025

Mining coral-derived terpene synthases and mechanistic studies of the coral biflorane synthase.

Bao Chen, Jingjing Mao, Kangwei Xu, Lijun Liu, Wei Lin, Yue-Wei Guo, Ruibo Wu, Chengyuan Wang, Baofu Xu

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Diversification of diterpene biosynthesis occurred early in octocoral evolution.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bao ChenShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.ORCID 0000-0001-6868-4996
Jingjing MaoShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0000-9599-3508
Kangwei XuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.ORCID 0009-0005-0134-0458
Lijun LiuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.ORCID 0009-0000-7555-5850
Wei LinNanjing Drum Tower Hospital, School of Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0002-2940-6966
Yue-Wei GuoShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.ORCID 0000-0003-0413-2070
Ruibo WuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.ORCID 0000-0002-1984-046X
Chengyuan WangShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-8605-0716
Baofu XuShandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China.ORCID 0000-0002-0144-2455

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biflorane diterpenoids are unique natural products often seen in marine animals. Recent studies have reported a small number of biflorane synthases. However, the catalytic mechanism and structural basis for biflorane formation remain unclear. To address these issues, we conducted genome mining of terpene synthases from the sea whip coral

Indexed as

Alkyl and Aryl TransferasesAnthozoaAnimalsCrystallography, X-RayCyclizationDiterpenesModels, MolecularTerpenesAlkyl and Aryl TransferasesDiterpenesTerpenesterpene synthase

Identifiers

PMID40009671
PMCPMC11864185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.