Evidence map›Paper›PMID 40009663›Full record

ArticleScience advances2025

The synaptonemal complex aligns meiotic chromosomes by wetting.

Spencer G Gordon, Alyssa A Rodriguez, Yajie Gu, Kevin D Corbett, Chiu Fan Lee, Ofer Rog

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Spencer G GordonSchool of Biological Sciences and Center for Cell and Genome Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-9787-406X
Alyssa A RodriguezDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.
Yajie GuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1514-1477
Kevin D CorbettDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-5854-2388
Chiu Fan LeeDepartment of Bioengineering, Imperial College London, London, UK.ORCID 0000-0003-4363-9050
Ofer RogSchool of Biological Sciences and Center for Cell and Genome Sciences, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0001-6558-6194

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Structure and dynamics of meiotic chromosomesR35GM128804 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ofer Rog · 2018 to 2026
$4.1M
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunityR35GM144121 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett · 2022 to 2026
$2.7M
NIGMS NIH HHS K12 GM068524NIGMS NIH HHS R35 GM128804NIGMS NIH HHS R35 GM144121NIH HHS P40 OD010440
6 · The paper itself

Abstract

During meiosis, the parental chromosomes are drawn together to enable exchange of genetic information. Chromosomes are aligned through the assembly of a conserved interface, the synaptonemal complex, composed of a central region that forms between two parallel chromosomal backbones called axes. Here, we identify the axis-central region interface in

Indexed as

Caenorhabditis elegansChromosomesMeiosisSynaptonemal ComplexAnimalsCaenorhabditis elegans ProteinsMutationCaenorhabditis elegans Proteins

Identifiers

PMID40009663
PMCPMC11864179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.