ArticleScience advances2025
Ambient outdoor heat and accelerated epigenetic aging among older adults in the US.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Practical considerations for characterization of the external exposome in Alzheimer's disease and related dementias cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Adaptation to heat stress by diversification of the vertebrate heat shock transcription factor family.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Data Considerations for Estimating Ambient Heat Exposure for Environmental Epidemiological Studies.Current environmental health reports · 2026Review
- Older adults and extreme weather events: recommendations from the Research Centers Collaborative Network workshop.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Association Between Extreme Climate Exposures and Bodily Pain: Evidence from the Chinese Health and Retirement Longitudinal Study.Journal of epidemiology and global health · 2026Article
- Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters.BMC medicine · 2026Article
- Health Risk Assessment of the Large-Scale Heat Waves - Northern China, 2023.China CDC weekly · 2026Article
- Climate Change, Epigenetics, Microbiota, and Health.International journal of environmental research and public health · 2026Review
- Joint associations of chronic heat exposure and physical activity with the risk of knee osteoarthritis: a prospective cohort study based on the UK biobank.BMC public health · 2026Article
- Heat Stress Modulates WDR5-Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Repair and regeneration across the lifespan: an ontogenetic perspective.Frontiers in aging · 2026Review
- Article
- Climate informed precision health.Frontiers in public health · 2026Article
- Warmer temperature accelerates senescence by modifying the aging-dependent changes in the mosquito transcriptome, altering immunity, metabolism, and DNA repair.Immunity & ageing : I & A · 2025Article
- Cryptic Reproductive Costs of Heatwaves for Animal Populations.Global change biology · 2025Review
- Article
- Ageing Trajectories: Exposome-Driven Pathobiological Mechanisms and Implications for Prevention from Blue Zones and Italian Longevity Hotspots Such as Cilento and Sicilian Mountain Villages.International journal of molecular sciences · 2025Review
- Burn Out Reimagined: Extreme Heat, Work Disability, and Sociodemographic Disparities in America.Generations (San Francisco, Calif.) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Extreme heat is well-documented to adversely affect health and mortality, but its link to biological aging-a precursor of the morbidity and mortality process-remains unclear. This study examines the association between ambient outdoor heat and epigenetic aging in a nationally representative sample of US adults aged 56+ (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.