Observational studyPloS one2025
Gait characteristics in idiopathic normal pressure hydrocephalus: A controlled study using an inertial sensor system.
Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04795089 (Gait Pattern, Experienced Global Change, Sense of Coherence, Quality of Life, Anxiety and Depression Symptoms After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus, in Relation With Healthy Individuals), which is not on this map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gait Pattern, Experienced Global Change, Sense of Coherence, Quality of Life, Anxiety and Depression Symptoms After Shunt Surgery in Idiopathic Normal Pressure Hydrocephalus, in Relation With Healthy Individuals
Who cites it
4 citing papers in PubMed.
- Perioperative real-life mobility assessment using wearable step counts in idiopathic normal pressure hydrocephalus after ventriculoperitoneal shunt surgery: a prospective pilot study.Neurosurgical review · 2026Article
- Sensor-derived heel pressure metrics capture reversible gait dysfunction beyond conventional gait measures in normal pressure hydrocephalus.Journal of neuroengineering and rehabilitation · 2026Observational
- Sensitivity of physiotherapy-based clinical tests in detecting change in gait and balance performance following a 50 mL CSF tap test in idiopathic normal pressure hydrocephalus.Fluids and barriers of the CNS · 2026Article
- Stratified screening-based cognitive measures reveals temporal patterns of recovery after the CSF tap test in idiopathic normal pressure hydrocephalus (iNPH): A single-centre retrospective study.Therapeutic advances in neurological disorders · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGait disturbance is the most pronounced symptom in idiopathic normal pressure hydrocephalus (iNPH). Some gait parameters have been previously described, but an in-depth description of the gait pattern is lacking. The aim was to quantitatively evaluate gait in iNPH patients before and after shunt surgery and compare it to healthy individuals (HI), and correlate it with functional tests preoperatively.
methodsIn total, 47 patients and 42 HI were included. The patients were assessed with the iNPH scale (total, gait and balance domain scores were analyzed), the timed up and go test (TUG) and an inertial sensor gait analysis system, RehaGait®, pre- and postoperatively. The HI were assessed with TUG and RehaGait®. Gait variables were: stride length, stride duration, velocity, cadence, variability, stance, swing, single support, double support, step height, hip, knee and ankle joint angles.
resultsCompared to HI, the main differences in the gait variables were: decreased stride length (p < 0.01), velocity (p < 0.01), swing time (p < 0.01), single support (p < 0.01), hip flexion (p < 0.01), heel strike angle (p < 0.01) and toe-off angle (p < 0.01). Step height was normalized postoperatively; all other variables remained significantly worse than the HI. There were strong correlations between stride length, velocity, heel strike angle, and toe-off angle and the functional gait tests, but no correlations for any variable and the balance domain score.
conclusionsThe patients walked with reduced hip flexion, heel strike angle and toe-off angle, and had shorter strides, decreased velocity, and increased time for swing and single support, compared to HI. Step height was the only gait variable normalized after shunt surgery. Ankle joint kinematics correlated strongly with the results in functional gait tests. More research is warranted about how gait speed affects other gait variables in iNPH.
trial registrationClinicalTrials.gov NCT04795089.
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