Evidence map›Paper›PMID 40009486›Full record

ArticleAmerican journal of audiology2025

Test-Retest Differences in the Wideband Middle Ear Muscle Reflex.

Naomi F Bramhall, Nicole K Whittle, M Patrick Feeney, Garnett P McMillan

Abstract read
In one paragraph

Article in American journal of audiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Rapid Characterization of Middle-Ear Muscle Reflexes Using Swept Elicitors.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Naomi F BramhallVA National Center for Rehabilitative Auditory Research (NCRAR) Veterans Affairs Portland Health Care System, OR.ORCID 0000-0003-1660-5322
Nicole K WhittleVA National Center for Rehabilitative Auditory Research (NCRAR) Veterans Affairs Portland Health Care System, OR.
M Patrick FeeneyVA National Center for Rehabilitative Auditory Research (NCRAR) Veterans Affairs Portland Health Care System, OR.ORCID 0000-0002-0647-5977
Garnett P McMillanVA National Center for Rehabilitative Auditory Research (NCRAR) Veterans Affairs Portland Health Care System, OR.

Funding

Mouse, Man, and Machine: Combining Model Systems to Develop a Biomarker for Cochlear Deafferentation in Humans (Administrative Supplement)R01DC020423 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Naomi Bramhall · 2022 to 2026
$3.3M
NIDCD NIH HHS R01 DC020423RRD VA I01 RX003804RRD VA I50 RX002361
6 · The paper itself

Abstract

purposeAssessment of the middle ear muscle reflex (MEMR) is a standard part of the clinical audiological test battery that is used to assess middle ear function and identify possible retrocochlear lesions. The use of a wideband MEMR probe allows for additional information across frequency and lower reflex thresholds compared to the standard tonal probe used clinically. Recent animal studies suggest that the wideband MEMR is sensitive to noise-induced cochlear synaptopathy, the selective loss of the synaptic connections between the inner hair cells and the afferent auditory nerve fibers. However, the clinical utility of the wideband MEMR as an indicator of cochlear deafferentation is still unclear. Prior to adoption of the wideband MEMR as part of a diagnostic battery for cochlear deafferentation, it is necessary to determine the test-retest reliability of the measurement.

methodIn a sample of 45 adults with normal hearing and normal tympanograms, wideband MEMR magnitude and threshold were measured at two different test sessions in response to a contralateral broadband noise stimulus at elicitor levels ranging from 60 to 100 dB SPL. The time between test sessions ranged from 2 hr to 5 months.

resultsTest-retest differences increased with elicitor level. In some individuals, there were changes in the magnitude and/or the frequency response of the MEMR between test sessions.

conclusionWhen wideband MEMR testing becomes clinically available, test-retest differences in contralateral wideband MEMR magnitude and threshold can be referenced by clinicians to help with interpretation of wideband MEMR test results. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.28454612.

Indexed as

Ear, MiddleReflex, AcousticAcoustic Impedance TestsAcoustic StimulationAdultAuditory ThresholdFemaleHumansMaleMiddle AgedReproducibility of ResultsYoung Adult

Identifiers

PMID40009486
PMCPMC13093139

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.